Other Alkylations

The direct reaction of other alkyl chlorides, such as butyl chloride, results in unacceptably low overall product yields along with the by-product butene resulting from dehydrochlorination. AH alkyl haHdes having a hydrogen atom in a P- position to the chlorine atom are subject to this complication. 

Benzyl groups, as well as other alkyl groups, can be converted to various carbamates as a variation of the von Braun reaction.The carbamates can then be cleaved by conditions that are outlined in the section on carbamates. 

Methyl p-toluenesulphonate. This, and other alkyl esters, may be prepared in a somewhat similar manner to the n-butyl ester with good results. Use 500 g. (632 ml.) of methyl alcohol contained in a 1 litre three-necked or bolt-head flask. Add 500 g. of powdered pure p-toluene-sulphonyl chloride with mechanical stirring. Add from a separatory funnel 420 g. of 25 per cent, sodium hydroxide solution drop by drop maintain the temperature of the mixture at 23-27°. When all the alkali has been introduced, test the mixture with litmus if it is not alkaline, add more alkali until the mixture is neutral. Allow to stand for several hours the lower layer is the eater and the upper one consists of alcohol. Separate the ester, wash it with water, then with 4 per cent, sodium carbonate solution and finally with water. Dry over a little anhydrous magnesium sulphate, and distil under reduced pressure. Collect the methyl p-toluenesulphonate at 161°/10 mm. this solidifies on cooling and melts at 28°. The yield is 440 g. 

Alkyl fluorides are more reactive than other alkyl halides under Friedel-Crafts conditions, whereas trifluoromethyl groups are less reactive than other trihalomethyl groups Thus, a bromoindane is prepared from 1-bromo-l-fluoro-2,2,3,3-tetramethylcyclopropane and benzene [5] (equation 8) whereas 3-tnfluo romethylphenyldiphenylchloromethane is obtained from 3-trifluoromethyl-benzotrichloride and benzene [9] (equation 9) 

Care must be exercised in handling n-amyl and the other alkyl nitrites inhalation of the vapour may cause severe headache and heart excitation. The preparation must therefore be conducted in an efficient fume cupboard. 

However, 17a,21-acetonides (103), as well as acetals of other ketones or aldehydes, can be easily prepared by acid-catalyzed exchange reaction with dimethoxypropane or other alkyl acetals in dimethylformamide or benzene. Enol etherification of the A -S-ketone also occurs with the former procedure. 

In silicon tetrachloride, SiC, chlorine atoms can be replaced by methyl or other alkyl groups to give, for example, CHjSiClj and (CH3)2SiCl2. These two compounds are obtained when methyl 

Dimethyl sulfide, CH3SO3H. Methyl phosphates are selectively cleaved in the presence of other alkyl phosphates.  

The most important reaction with Lewis acids such as boron trifluoride etherate is polymerization (Scheme 30) (72MI50601). Other Lewis acids have been used SnCL, Bu 2A1C1, Bu sAl, Et2Zn, SO3, PFs, TiCU, AICI3, Pd(II) and Pt(II) salts. Trialkylaluminum, dialkylzinc and other alkyl metal initiators may partially hydrolyze to catalyze the polymerization by an anionic mechanism rather than the cationic one illustrated in Scheme 30. Cyclic dimers and trimers are often products of cationic polymerization reactions, and desulfurization of the monomer may occur. Polymerization of optically active thiiranes yields optically active polymers (75MI50600). 

Substitution at the Carbon—Chlorine Bond. Vinyl chloride is generally considered inert to nucleophilic replacement compared to other alkyl halides. However, the chlorine atom can be exchanged under nucleophilic conditions in the presence of palladium [7440-05-3] Pd, and certain other metal chlorides and salts. Vinyl alcoholates, esters, and ethers can be readily produced from these reactions. 

A review covers the preparation and properties of both MABS and MBS polymers (75). Literature is available on the grafting of methacrylates onto a wide variety of other substrates (76,77). Typical examples include the grafting of methyl methacrylate onto mbbers by a variety of methods chemical (78,79), photochemical (80), radiation (80,81), and mastication (82). Methyl methacrylate has been grafted onto such substrates as cellulose (83), poly(vinyl alcohol) (84), polyester fibers (85), polyethylene (86), poly(styrene) (87), poly(vinyl chloride) (88), and other alkyl methacrylates (89). 

The reactivity of sulfathiazoles has been reviewed (65). Methylation in alkaline solution with dimethyl sulfate gives only the ring methylated derivative (85). Mixtures of products are obtained with diazomethane as alkylating agent (see p. 37). Other alkyl halides in aqueous alkali lead also to ring-alkylated products (85. 251, 650. 669-671). 

Table 15 shows that peroxyester stabiUty decreases for the alkyl groups in the following order tert — butyl > tert — amyl > tert — octyl > tert — cumyl > 3 — hydroxy — 1,1 dimethylbutyl. The order of activity of the R group in peroxyesters is also observed in other alkyl peroxides. Peroxyesters derived from benzoic acids and non-abranched carboxyUc acids are more stable than those derived from mono-a-branched acids which are more stable than those derived from di-a-branched acids (19,21,168). The size of the a-branch also is important, since steric acceleration of homolysis occurs with increasing branch size (236). Suitably substituted peroxyesters show rate enhancements because of anchimeric assistance (168,213,237). 

Various alkylating agents are used for the preparation of pyridazinyl alkyl sulfides. Methyl and ethyl iodides, dimethyl and diethyl sulfate, a-halo acids and esters, /3-halo acids and their derivatives, a-halo ketones, benzyl halides and substituted benzyl halides and other alkyl and heteroarylmethyl halides are most commonly used for this purpose. Another method is the addition of pyridazinethiones and pyridazinethiols to unsaturated compounds, such as 2,3(4//)-dihydropyran or 2,3(4//)-dihydrothiopyran, and to compounds with activated double bonds, such as acrylonitrile, acrylates and quinones. 

Acryhc elastomers are normally stable and not reactive with water. The material must be preheated before ignition can occur, and fire conditions offer no hazard beyond that of ordinary combustible material (56). Above 300°C these elastomers may pyrolize to release ethyl acrylate and other alkyl acrylates. Otherwise, thermal decomposition or combustion may produce carbon monoxide, carbon dioxide, and hydrogen chloride, and/or other chloiinated compounds if chlorine containing monomers are present ia the polymer. 

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