Oropharyngeal carcinoma

An in-vitro electrochemical treatment (ECT) of KB cells from a human oropharyngeal carcinoma line has been carried out by Yen and coworkers 61 inhibition of cell growth in culture was observed and found to depend on the magnitude of current and treatment time. Results were interpreted in terms of pH effects caused by ECT. 

A randomized study comparing carboplatin/5-FU/radiotherapy vs radiotherapy in patients with locally advanced oropharyngeal carcinoma was recently reported by the French Group of Radiation Oncology for HNC (GORTEC) (54). Two hundred twenty-six patients were randomized to conventional radiotherapy or identical radiotherapy combined with three cycles of the 4-d regimen of carboplatin (70 mg/m2/d) and continuous infusion 5-FU (600 mg/m2/d) on d 1,22, and 43 of radiation. Increased mucositis was reported in the combined modality arm 67% vs 36%. No difference in skin toxicity was... 

Horiot JC, Le Fur R, N Guyen T, et al. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol 1992 25 231-241. 

Vartanian JG, Pontes E, Agra IM, et al. Distribution of metastatic lymph nodes in oropharyngeal carcinoma and its implications for the elective treatment of the neck. Arch Otolaryngol Head Neck Surg. 2003 129(7) 729-732. 

H. H. (1998) In situ infrared histopathology of keratinization in human oral/oropharyngeal squamous cell carcinoma. Oncol. Res., 10, 277-85. 

CCR7 expression was positively correlated with regional LN metastasis in T1 breast cancer [21], cervical cancer [22], melanoma [23], colorectal carcinoma [24], gastric carcinoma [25, 26], oral and oropharyngeal squamous cell carcinoma [27], squamous cell carcinoma of tonsil [28], esophageal squamous cell carcinoma [29], squamous cell carcinoma of the head and neck (SCCHN) [30], thyroid carcinoma [31], nonsmall cell lung cancer [32], hepatocellular cancer [33], prostate cancer [34], adult T-cell leukemia [35], and chronic lymphocytic leukemia [36, 37]. 

CCR7 expression was also highly correlated with reduced disease-free and overall survival, more progressive stages, higher rates of local recurrence, and cancer death in patients with oral and oropharyngeal squamous cell carcinoma [27]. Analysis of patients with tonsillar squamous cell carcinoma revealed a... 

Tsuzuki, H., N. Takahashi, A. Kojima, N. Narita, H. Sunaga, T. Takabayashi, and S. Fujieda. 2006. Oral and oropharyngeal squamous cell carcinomas expressing CCR7 have poor prognoses. Auris Nasus Larynx 33 37-42. 

Metal-based drugs have probably had most impact in the area of cancer therapy, with cisplatin still used to treat approximately 70% of all cancer patients. Cisplatin is particularly useful for treatment of testicular, ovarian, oropharyngeal, bronchogenic, cervical, and bladder carcinomas, lymphoma, osteosarcoma, melanoma, and neuroblastoma. Metallocene-type compounds were the first organometallic compounds to be evaluated in cancer therapy, and until recently, Ti(77 -C5H5)2Cl2 was undergoing clinical trials (see above). Despite this setback to the field,... 

Papovaviridae papovaviridae is a DNA virus family containing double-stranded DNA. The human papillomavirus is the most important member of this virus family, usually associated with cervical intraepithelial dysplasia and squamous cell carcinoma, skin tumors and tumors of the oropharyngeal region. The second member of this virus family is the polyomavirus associated with other animal tumors. 

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