Ornithine decarboxylase curcumin

Rao, C.V., Simi, B., and Reddy, B.S., Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis (London), 14, 2219, 1993. 

The effect of curcumin on apoptosis in multidmg-resistant cell lines has been reported. Piwocka et al. ° demonstrated that curcumin induced cell death in multidrag-resistant CEM(P-gp4) and LoVo(P-gp4) cells in a caspase-3-independent maimer. Mehta et al. also examined the antiproliferative effects of curcumin against multidrag-resistant (MDR) lines, which were found to be highly sensitive to curcumin. The growth-inhibitory effect of curcumin was time- and dose-dependent and was correlated with its inhibition of ornithine decarboxylase activity. Curcumin preferentially arrested cells in the G2/S phase of the cell cycle. 

Lu, Y.P., Chang, RE., Huang, M.-T., and Conney, A.H. (1993) Inhibitory Effects of Topical Application of Low Doses of Curcumin on 12-0-Tetradecanoylphorbol-13-ac-etate-Induced Increase in Ornithine Decarboxylase mRNA in Mouse Epidermis, Carcinogenesis 14,293-291. 

Like many other antioxidants, rosemary and its polyphenols possess not only antioxidative activities, but also antitumorigenic activities. Huang et al. (5) investigated the inhibitory effects of rosemary extract, carnosol and ursolic acid on tumor formation in mouse skin. They found that topical application of rosemary inhibits B(a)P- and DMBA-induced initiation of tumor and TPA-induced tumor promotion in DMBA-initiated mice. Carnosol and ursolic acid were found to be strong inhibitors of TPA-induced inflammation, ornithine decarboxylase activity and tumor promotion in mouse skin (5). It was suggested that carnosol acted like other nonsteroidal phenolic anti-inflammatory agents, such as curcumin, which inhibited the metabolism of arachidonic acid. 

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