Orientation methodologies

Keller, R, and Tchernev, N. (1997), Object Oriented Methodology for FMS Modeling and Simulation, International Journal of Computer Integrated Manufacturing, Vol. 10, No. 6, pp. 405-434. 

The research followed a design-oriented methodology similar to the one applied by Verdouw et al. (2010) to develop a reference process modeling for the fruit industry in Europe to become a demand driven supply chain. 

The presented description of the exertion-oriented methodology can be finalized as follows ... 

While it is true that to master this technique is to provide dramatic increases in productivity, the sad fact of the matter is that object-oriented development, if done inappropriately, can cause problems far greater than problems generated from structured techniques. The reason for this is simple the stakes are higher. Object-oriented environments are more complex than any other, the business problems chosen to be solved by object-oriented techniques are far more complex than other types of problems, and there are no conventional object-oriented methodologies and corollary tools to help the development team develop systems that are truly reliable. There are many kinds of object orientation. But with this diversity comes some very real risks. As a result, the following developmental issues must be considered before the computer is even turned on. 

Control system design has been organized into a logical, sequential, process-oriented methodology by... 

Recently, Burger devised an improved method of carrying out mild, regiospecific cyclizations that involve an intermediate that acts as a synthon for a nitrile ylide of HCN [47 (equation 48). With this methodology, cycloadditions with activated alkenes, alkynes, and azo compounds were earned out [47] (equation 49). All such reported reactions were regiospecific and had the same orientational preference... 

The SPEAR framework to be described in subsequent sections is designed to be used either as a stand-alone methodology, to provide an evaluation of the human sources of risk in a plant, or in conjunction with hardware orientated analyses to provide an overall system safety assessment. The overall structure of the framework is set out in Figure 5.4. 

PROBLEM DEFINITION. This is achieved through plant visits and discussions with risk analysts. In the usual application of THERP, the scenarios of interest are defined by the hardware orientated risk analyst, who would specify critical tasks (such as performing emergency actions) in scenarios such as major fires or gas releases. Thus, the analysis is usually driven by the needs of the hardware assessment to consider specific human errors in predefined, potentially high-risk scenarios. This is in contrast to the qualitative error prediction methodology described in Section 5.5, where all interactions by the operator with critical systems are considered from the point of view of their risk potential. 

The Bowyer and Bader [96] methodology can be used to predict stress-strain response of short fiber-rein-forced plastics. The stress on the composite (cT( ) at a given strain can be computed by fitting the response to a form of Eq. (4) with two parameters, the fiber orientation factor (Cfl) and interfacial shear strength (t,). 

The total synthesis of palytoxin (1) is a landmark scientific achievement. It not only extended the frontiers of target-oriented synthesis in terms of the size and complexity of the molecules, but also led to new discoveries and developments in the areas of synthetic methodology and conformational analysis. Among the most useful synthetic developments to emerge from this synthesis include the refinement of the NiCh/CrC -mediated coupling reaction between iodoolefins and aldehydes, the improvements and modifications of Suzuki s palladium-catalyzed diene synthesis, and the synthesis of A-acyl vinylogous ureas. 

The Rh2(DOSP)4 catalysts (6b) of Davies have proven to be remarkably effective for highly enantioselective cydopropanation reactions of aryl- and vinyl-diazoacetates [2]. The discovery that enantiocontrol could be enhanced when reactions were performed in pentane [35] added advantages that could be attributed to the solvent-directed orientation of chiral attachments of the ligand carboxylates [59]. In addition to the synthesis of (+)-sertraline (1) [6], the uses of this methodology have been extended to the construction of cyclopropane amino acids (Eq. 3) [35], the synthesis of tricyclic systems such as 22 (Eq. 4) [60], and, as an example of tandem cyclopropanation-Cope rearrangement, an efficient asymmetric synthesis of epi-tremulane 23 (Eq. 5) [61]. 

Certain computational methodologies such as some approaches to quantitative structure-activity relationship (QSAR) studies use 3D ligand structures [37, 38]. These methods generally assume that a bioactive conformation has been estab-Hshed for a set of molecules and that these conformers can be ahgned in a maimer that reflects the relative orientation they would adopt in a binding site. It is thus... 

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