Organs haematologic effects

Trichocethecens possess a range of toxic effects. The acute trichocethecen toxicity manifests as intestine disorders (vomiting, temperature, diarrhoea etc.). There are also haematological effects such as anemia and reduction of the number of leucocytes. These toxins suppress the synthesis of proteins in the organism. 

Pickering RG, Pickering CE (1984) The effects of reduced dietary intake upon the body and organ weights, and some clinical chemistry and haematologic variates of the young Wistar rat. Toxicol Lett 21 271-277 Price RG (2002) Early markers of nephrotoxicity. Comp Clin Pathol 11 2-7... 

The information required to evaluate specific target organ/systemic toxicity comes either from repeated exposure in humans, e.g. exposure at home, in the workplace or environmentally, or from studies conducted in experimental animals. The standard animal studies in rats or mice that provide this information are 28 day, 90 day or lifetime studies (up to 2 years) that include haematological, clinico-chemical and detailed macroscopic and microscopic examination to enable the toxic effects on target... 

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