Organophosphates bioscavengers

Mazor, O., Cohen, O., Kronman, C., et ah, 2008. Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase. Mol. Rharmacol. 74, 755-763. 

Doctor BP, Saxena A (2005) Bioscavengers for the protection of humans against organophosphate toxicity. Chem-Biol Interact 157-158 167-171... 

Doctor, B.P., Maxwell, D.M., Saxena, A. (1997). Preparation and characterization of bioscavengers for possible use against organophosphate toxicity. m-CB Medical Treatment Symposium, May 26-30, 1997, Hradec Kralove. Abstracts, pp. 17-18. 

Protection of Acetylcholinesterase from Organophosphates Kinetic Insight into Bioscavengers... 

Josse, D., Broomfield, C.A., Cerasoli, D., Kirby, S., Nicholson, J., Bahnson, B., and Lenz, D.E. 2002 Engineering of HuPONI for a Use as a Catalytic Bioscavenger in Organophosphate Poisoning, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD. 

As described above (see Section VILA), soluble ChE and oxime together detoxify OP compounds. These features were combined to developed a sponge product composed of ChE (FBS-AChE and EqBChE), organophosphate hydrolase (rabbit or bacterial OPH), oxime (2-PAM or HI-6), and polyurethane foam combinations for the removal and decontamination of OP compounds from medically important biological surfaces such as skin. This is an important extension of the bioscavenger approach to external decontamination and protection against organophosphate toxicity, since currently... 

Trovaslet-leroy, M., Musilova, L., Renault, E, et al., 2011. Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents. Toxicol. Lett. 206,14-23. 

Cohen, O., Kronman, C., Raveh, L., et al., 2006. Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds. 

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