Organometallic chemistry enzyme catalysis

C. Zerner, Michael J. Scott and C. Russell Bowers. He then joined Michael B. Hall s research group at Texas A M University and is currently an Assistant Research Scientist. His research focuses on using theoretical and computational chemistry to research and answer questions in a variety of areas, including biological enzyme catalysis, catalytic and stoichiometric mechanisms of bond activation and functionalization of organic molecules by organometallic transition metal complexes, and the elucidation of structure and bonding of various compounds of interest. 

The organometallic chemistry of molybdenum has been reviewed and papers published in 1971 dealing with this area of chemistry for molybdenum and tungsten have been surveyed. " Reviews discussing aspects of catalysis by tungsten compounds and the geochemical cycle of molybdenum in the environment have been published. Coupled proton-electron transfer mechanisms have been proposed for the action of molybdenum in several enzymes to explain many experimental observations. ... 

Metallomicellar-catalyzed reactions, inclnding hydrolysis, oxidorednction, and C—C bond formation, might characterize these snpramolecular objects as metalloenzyme mimics that use hydrophobic microenvironment and active centers in constrained domains. In this direction, formal approaches using Michaelis-Menten methods known for enzyme chemistry were applied to kinetics characterization of micellar catalysis. In addition, recent achievements of advanced organometallic reactions such as Heck, Suzuki, and Sonogashira couplings as well as olefin metathesis, directly in water and at room temperature, make the use of surfactants particularly promising to lower the environmental impact, which has become a requirement for the chemical industry in the past years. ... 

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