Organ weight changes

Sorensen, E.M.B., P.M. Cumbie, T.L. Bauer, J.S. Bell, and C.W. Harlan. 1984. Histopathological, hematological, condition-factor, and organ weight changes associated with selenium accumulation in fish from Belews Lake, North Carolina. Arch. Environ. Contam. Toxicol. 13 153-162. 

No histopathological or organ weight changes were noted in the respiratory system of male mice following daily dermal exposures for 1 week to 0.1 mL kerosene (Upreti et al. 1989) 13-week exposures to 2,000-8,000 mg/kg/day JP-5 or chronic exposures to 250 or 500 mg/kg/day of either marine diesel fuel or JP-5 (NTP/NIH 1986). 

No measurable effect in females, based on clinical chemistry, hematology, routine histopathology, and organ weight changes (USEPA 1980)... 

In another 13-week study, rats that were fed the compound up to a maximum level of 252 mg tin/kg/day as stannous chloride, showed increased relative kidney weights (Dreef-van der Meulen 1974). The protein-like droplets and calcareous deposits which are common in the rat strains used were present in the controls but were not seen in the tin-fed animals. The absence of calcareous deposits in the females confirms the observations of DeGroot et al. (1973), but the relevance of these finding to compound toxicity is unclear. The organ weight change itself, in the absence of histopathological or other effects, cannot be considered a toxic effect. 

In animals, no histological or organ weight changes were observed in livers of Fischer 344 rats or Hartley guinea pigs exposed by inhalation (6 hours/day, 5 days/week) to 6.1 mg Al/m3 as aluminum chlorhydrate for 6 months (Steinhagen et al. 1978). 

In addition to causing lymphoid organ weight changes, 2,3,7,8-TCDD has been shown to cause functional alterations in the immune response (Vecchi et al. 1980a). Studies have shown that suppressed... 

In Fischer 344 rats, exposure to cumene vapor for 13 weeks resulted in mild toxicity at 1200 ppm, minimal effects at 500 ppm, and no-observed effects at 50 and 100 ppm the main effects were reversible decreased activity, reversible organ weight changes, and male rat renal hyaline droplet formation, which is not believed to be relevant to humans. Neurotoxi-cological effects were not observed in this study, which included complete batteries of functional and motor activity tests and neurohistopathology. 

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