Oncolytic drug

Plastic containers are also widely used for packaging parenteral products, such as intravenous (IV) infusion fluid containers, irrigation fluid containers, prefilled disposable syringes, and some administration sets. Polymeric containers have an added advantage of low breakage and are preferred when the SVP product is a highly toxic material such as oncolytic drugs. Typical polymeric... 

In spite of their close (chemical) similarity, a somewhat different group of human neoplasms responds to these compounds, and there has been a singular lack of cross-resistance between these two drugs and other oncolytic drugs now in wide use. 

Table 5.22 Pharmacokinetics, patient characteristics, and adverse event data for a new oncolytic drug.

The mechanism ol action of ihe oncolytic drugs deriNCd from I imti rou o. I.ins. 

Armstkong, j. G., The Mechanism of Action of the Oncolytic Drugs Derived from Vinca rosea Linn. Gann Monograph, No. 2, Maruzen, Tokyo, 1967. 

Xu W, Zhang Z, Castaner J (2001) Atofluding. Oncolytic. Drugs Future 26 935-938... 

In October 2003, the SFDA approved the world s first gene therapy— Gendicine (a recombinant human adenovirus type 5 mediated delivery of p53 gene)— for the treatment of head and neck cancer. In 2005, another head and neck cancer drug, Oncorine (a recombinant oncolytic adenovirus type 5), was approved. In the same year, another recombinant human endostatin, Endostar, was approved for the treatment of small-cell lung cancer. 

Preclinical and Clinical Drug Development of Tasidotin, a Depsi-Pentapeptide Oncolytic Agent... 

Phosphorous Containing Polymers Synthetic Nanoparticles, Drug Conjugates Oncolytic and CNS therapeutics, DNA delivery... 

Dendrimers Synthetic Controlled and sustained drug delivery, bacterial infection, antiviral, vaccine and gene therapy Oncolytic agent Methotrexate,Paclitaxel, Docetaxel, Dithranol... 

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