ONCOL structure

The downward systemic movement of ONCOL (structure given earlier), a new insecticide derived from carbofuran, has been observed (19). A significant amount of radioactivity was observed in the roots of cotton and bean plants treated topically at the base of bifoliate or trifoliated leaves with [carbamate carbonylONCOL. Downward movement of the radiolabeled material may be explained by hydrolytic degradation of the ethoxycarbonyl moiety in ONCOL to the carboxylic acid derivative, the acid function serving as a downward moving carrier. 

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Fig. 2. Structure of the ABLl kinase portion of the BCR-ABLl protein. The activation loop (blue) is in the closed (inactive) conformation on the left and in the open (active) conformation on the right. A molecule of imatinib is positioned in the ATP-binding site and is in green. (Reprinted with permission from U S. Healthcare Communications, LLC. LitzowMR, Tefferi A. Chronic myeloid leukemia problems propel progress. Amer J Hematol/Oncol, 2007 6(5) supplement 7 19-22).

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