On-Chip Electrospray

Chip electrospray mass speclrometiy Electrospray emitter on-chip Electrospray ionization mass spectrometry (ESI-MS) Electrospray mass spectrometry... 

On-Chip Electrospray, Fig. 1 Taylor cone formation at the tip of a 100 pm capillary across which a 3 kV DC voltage is applied. A slcmdca jet issues from the tip of the TaylOT cone as a result of Rayleigh fission, subsequently breaking up to fium aerosol droplets... 

On-Chip Electrospray, Fig. 2 Schematic illustration of the Couiombic fission process occurring during DC electrospraying, giving rise to successively smaller charged drops... 

Progress in the development of on-chip electrospray interfaces for mass spectrometry has grown exponentially over the past two decades. While there are many different designs and methods proposed, it is possible to summarize these developments in general into three... 

On-Chip Electrospray, Fig. 3 Schematic diagram representing the multichannel ESI-MS chip device in Xue et al. [12]. Each channel was connected to two reservoirs for sample injection and delivery. A syringe pump attached to the second reservoir of each channel was used... 

Subsequent developments in the on-chip electrospray then involved using either a transfer capillary or a microfabricated emitter tip as a dedicated electrospray orifice in order to more efficiently address these problems. 

On-Chip Electrospray, Fig. 4 On-chip ESI-MS device employing a fused silica transfer capillary. The electric contact was established through a stainless steel capillary connected to the silica capillary using a poly(tetrafluor-oethylene) sleeve. Another fused silica capillary... 

On-Chip Electrospray, Fig. 5 Schematic diagram (top) and image (bottom) of the ESI-MS device involving a transfer capillary and a subatmospheric liquid junction (Reprinted with permission from [23])... 

On-Chip Electrospray, Fig. 6 Scanning electron microscopy images of an out-of-plane needle electrospray emitter tip fabricated at the bottom side of a liquid chamber etched into a silicon wafer. The view from the bottom is depicted in image (a) showing the 10 pm diameter needle protruding from the underside of the substrate. The view from the top of the substrate is depicted in image (b) showing the 600 pm liquid chamber (Reprinted with permission from [9])... 

On-Chip Electrospray, Fig. 7 Scanning electron microscopy image (a) and schematic plan and side views (b) of the nib-like in-plane electrospray emitter tip fabricated in SU-8 epoxy using double-exposure lithography [20] (Reprinted with permission from [20])... 

Liuni, R, Rob, T., Wilson, D.J. (2010) A Microfluidic Reactor for Rapid, Low-pressure Proteolysis with On-chip Electrospray Ionization. Rapid Commun. Mass... 

On-ChIp Electrospray, Rgure 1 Taylor cone formation at the tip of a... 

Progress in the development of on-chip electrospray interfaces for mass spectrometry has grown exponentially over... 

The first miniaturized on-chip electrosprays consisted of a planar glass microchip with 60 p,m wide and 10 xm deep etched channels [11]. The open-end channel exit... 

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