Oligosaccharides, mass spectrometry

Z. Zhou, S. Ogden and J.A. Leary, Linkage position determination in oligosaccharides mass spectrometry (MS/MS) study of lithium-cationized carbohydrates, J. Org. Chem., 55 (1990) 5444-5446. 

Zala, J., Mass spectrometry of oligosaccharides. Mass Spectrometry Reviews, 23,161-227, 2004. 

Xylans as true homopolymers occur in seaweeds of the Palmariales and Nemaliales, however, their backbone consists of Xylp residues linked by -(1 3) (Type X3, Fig. la) or mixed -(1 3, 1 -> 4)-glycosidic linkages (Type Xmy Fig. lb). They are assumed mainly to have a structural function in the cell-wall architecture, but a reserve function cannot be ruled out [4]. From the microfibrils of green algae (Siphonales) such as Caulerpa and Bryop-sis sp., X3 was isolated and the structure confirmed by methylation analysis, C-NMR spectroscopy [7], as well as by mass spectrometry of enzymically released linear oligosaccharides up to a degree of polymerization (DP) of... 

Figure 5.9 Principal oligosaccharide structures found on recombinant rituximab. Reprinted from J. Chromatogr., A, 913, Wan, H. Z., Kaneshiro, S., Frenz, J. and Cacia, J., Rapid method for monitoring galactosylation levels dnring recombinant antibody production by electrospray mass spectrometry with selective-ion monitoring , 437-446, Copyright (2001), with permission from Elsevier Science.

The structures of many oligosaccharide chains can be elucidated by gas-liquid chromatography, mass spectrometry, and high-resolution NMR spectrometry. Glycosidases hydrolyze specific linkages in oligosaccharides and are used to explore both the structures and functions of glycoproteins. 

Mo, W., Sakamoto, H., Nishikawa, A., Kagi, N., Langridge, J.I., Shimonishi, Y., and Takao, T., Structural characterization of chemically derivatized oligosaccharides by nanoflow electrospray ionozation mass spectrometry, Anal. Chem., 71, 4100, 1999. 

L. M. Mallis, H. M. Wang, D. Loganathan, and R. J. Linhardt. Sequence Analysis of Highly Sulfated, Heparin-Derived Oligosaccharides Using Fast Atom Bombardment Mass Spectrometry. Anal. Chem., 61(1989) 1453-1458. 

Field M., Papac D., and Jones A. (1996), The use of high-performance anion-exchange chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to monitor and identify oligosaccharide degradation, Anal. Biochem. 239, 92-98. 

Karlsson, N.G. Karlsson, H. Hansson, G.C. Sulfated Mucin Oligosaccharides From Porcine Small Intestine Analyzed by Four-Sector Tandem Mass Spectrometry. J. Mass Spectrom. 1996, 31. 560-572. 

Zamfir A, Seidler DC, Kresse H, Peter-Katalinic J. 2002. Structural characterization of chondroitin/dermatin sulfate oligosaccharides from bovine aorta by capillary electrophoresis and electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom 16 2015. 

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