Of isopropanolamine

Following a plant incident in which the crude aldehyde had polymerised during distillation, it was found that the presence of 2% of isopropanolamine (a probable impurity) led to an explosive polymerisation reaction. It is conceivable that aldehydic peroxides may also have been involved. 

The alkylation of pyrroles 131 with epichlorohydrin using potassium carbonate as a catalyst affords l-(2-oxiranyl-methyl)-l/7-pyrroles 132 in modest to high yields (Equation 22) <2002BMC2511>. A similar synthetic route led to indole derivatives 133 (Equation 23). Both compounds 132 and 133 are precursors of isopropanolamines, potential anti-HIV-l-PR agents. 

Properties Crystalline, white solid. Mild base (a mixture of isopropanolamines that has density of 1.004—1.010 and is liquid at room temperature is also marketed). D 0.9996 (50/20C), mp 45C, bp 305C, vap press below 0.01 mm Hg (20C), viscosity 1.38 cP (60C), flash p 320F (160C) (OC). Soluble in water. Combustible. 

CAS 68003-13-4 EINECS/ELINCS 268-109-8 Synonyms Boric acid (H3BO3), compd. with 1-amino-2-propanol (1 1) Boric acid, monoisopropanolamine salt (2-Hydroxypropyl) ammonium dihydrogen orthoborate 2-Hydroxypropylammonium orthoborate Isopropanolamine borate Monoisopropanolamine borate Definition Reaction prod, of isopropanolamine and boric acid... 

Definition Blend of isopropanolamine, diisopropanolamine, and triisopropanolamine Uses Buffer in cosmetics Mixed isopropanolamines lanolate CAS 85536-46-5 85536-47-6 EINECS/ELINCS 287-529-2 287-530-8... 

As summarized in Table 10, fatty acid ethanolamide and ethoxylated fatty ethanolamide may be quantitatively analyzed by TLC on silica, using iodine vapor for visualization of the ethanolamide and Dragendorff reagent for the ethoxylated compounds, which are separated by chain length (57,58). Either silica gel impregnated with dodecanol or alumina plates allow differentiation of mono- and dialkanolamides (7). Reversed-phase systems will differentiate alkanolamides according to alkyl chain length (14). A 3-plate system allows determination of isopropanolamine and amide, mono-and diethanolamine and amide, and polydiethanolamide in commercial fatty acid alkanolamide surfactant (59). The latroscan technique (flame ionization detection) can also be used with multiple development to analyze these compounds (60). 

Etliyleiie oxide [75-21-8] propylene oxide [75-56-9] or butylene oxide [106-88-7] react widi aminonia to produce alkanolainines (Table 1). Etlianolainines, (n = 1, 2,3, mono-, di-, and tri-), are derived from the reaction of ammonia witli ethylene oxide. Isopropanolamines,... 

A variety of substituted alkanolamines ate also available cormiierciaUy, but have not readied die volume popularity of die edianolamines and isopropanolamines (see Table 2). 

A brief summary of safety and health hazards follows detailed health hazards, however, should be obtained from producers by requesting Material Safety Data Sheets. Proper protective equipment and exposure hazards should be noted before handling any alkan olamine. Detailed toxicological testing is found in the CTEA Chemical Ingredient Review Board Reports on ethanolamines and isopropanolamines (24). 

Ammonia, and Amines. Isopropanolamine is the product of propylene oxide and ammonia ia the presence of water (see Alkanolamines). Propylene oxide reacts with isopropanolamine or other primary or secondary amines to produce A/- and A/,A/-disubstituted isopropanolamines. Propylene oxide further reacts with the hydroxyl group of the alkanolamines to form polyether polyol derivatives of tertiary amines (50), or of secondary amines ia the presence of a strong base catalyst (51). 

Isopropa.nola.mines. Reaction of propylene oxide with ammonia yields mono-, di-, and triisopropanolamines. These products find use as soluble oils and solvents, emulsifiers, waterless hand cleaners, cosmetics, cleaners, and detergents. In industrial apphcations isopropanolamines are used in adhesives, agricultural products, corrosion inhibitors, coatings, epoxy resins, metalworking, and others (51). 

Other lipophilic groups possibly attached to the maleic acid anhydride are alkanolamides of fatty acids. In this case the variations could be chain length and/or saturation grade of the C chain, the type of alkanolamine (most common are isopropanolamine, monoethanolamine, and diglycolamine), or an etho-... 

Propylene oxide (PO) is an important intermediate in the manufacture of a wide range of valuable products propylene glycol, ethers, isopropanolamines, and various propoxylated products for polyurethanes (1). The current processes for the large scale synthesis of PO include (i) the chlorohydrin process and (ii) the peroxide process (1, 2). 

Adip [Possibly an acronym of DIPA, di-isopropanolamine] A process for removing hydrogen sulfide, mercaptans, carbonyl sulfide, and carbon dioxide from refinery streams by extraction into an aqueous solution of di-isopropanolamine or methyl diethanolamine. Developed and licensed by the Shell Oil Company, Houston, TX. More than 320 units were operating in 1992. 

Sulfinol A process for removing hydrogen sulfide, carbon dioxide, carbonyl sulfide, and organic sulfur compounds from natural gas by scrubbing with di-isopropanolamine dissolved in a mixture of sulfolane and water. Developed in the 1960s by Shell International Research Mij N.V, The Netherlands and Shell Development Company, Houston. In 1996, over 180 commercial units were operating or under construction. 

The general concept of the synthesis of hyperbranched polyesteramides allows the use of any secondary amine with at least two )5-hydroxyalkyl groups such as diisobutanolamine or di- -cyclohexanolamine for the build-up of the highly branched structure. In the case of secondary mono )5-hydroxyalkyl amines, e.g., methyl isopropanolamine, one obtains linear polymers. Primary amines cannot be used as they form imides in the polycondensation step. 

Langvardt, P. W. Melcher, R. G. Determination of Ethanol- and Isopropanolamines in Air at Parts-Per-Billion Levels Anal. Chem., 1980, 52, 669. 

The identity of the metabolite has not yet been established, but it is neither the deacetylated nor 3-hydroxy metabolite found in vivo. However, deacetylation may be a prerequisite for the N-hydroxylation reaction, which has been suggested. Although the exact antigenic determinants of the metabolite have not been elucidated, it is known that the complete isopropanolamine side chain is necessary. 

Isopropanolamines, NH3 (CH2CHOHCH3), result from the reaction of ammonia with propylene oxide. Secondary butanolamines, NH3 (CH2CHOHCH2CH3), are the result of the reaction of ammonia with butylene oxide. Mixed alkanolamines can be produced from a mix-... 

Low temperature methanol Dimethyl ethers of polyethylene glycol Di-isopropanolamine dissolved in sulfolane and water Monoethanolamine (MEA) or diglycolamine... 

The corrin ligand and the basic motif of the nucleotide chain are widely conserved structural units in the natural corrins. Norpseudovitamin B12 (8) is the first example of a natural corrinoid with a modified isopropanolamine linker it is (the isolation form of) the cofactor of perchloroethene-dehalogenase in an obligate anaerobe. The nucleotide bases (a 5,6-dimethylbenzimidazole in the cobalamins) of natural complete corrins from different bacterial sources also exhibit variability in their constitution (Figure 2). ... 

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