Of ethyl methyl ketone

Acetone may be used as solvent in place of ethyl methyl ketone, but the reaction must then be carried out in a sealed vessel at 95-100° for thirty to thirty-six hours. 

The arylhydrazone 24 generally gives the 3-alkyl-2-methylindole 25 as major product. However, the indolization of ethyl methyl ketone has been reported to provide both 2,3-dimethyl indole and 2-ethyl indole. " ... 

A mixture of 60 g (0.408 mol) of isatin, 200 mL of 34% potassium hydroxide in diluted alcohol solution, 88 g (1.22 mol) of ethyl methyl ketone and 375 mL of water were stirred and heated under reflux for 72 hours. About 125 mL of liquid was removed by distillation the residue was made slightly acidic and filtered. The filtrate was made strongly acidic to precipitate the reaction product, which was collected by filtration, washed, dried, weighed 70 g (85% yield). 

A thioamide of isonicotinic acid has also shown tuberculostatic activity in the clinic. The additional substitution on the pyridine ring precludes its preparation from simple starting materials. Reaction of ethyl methyl ketone with ethyl oxalate leads to the ester-diketone, 12 (shown as its enol). Condensation of this with cyanoacetamide gives the substituted pyridone, 13, which contains both the ethyl and carboxyl groups in the desired position. The nitrile group is then excised by means of decarboxylative hydrolysis. Treatment of the pyridone (14) with phosphorus oxychloride converts that compound (after exposure to ethanol to take the acid chloride to the ester) to the chloro-pyridine, 15. The halogen is then removed by catalytic reduction (16). The ester at the 4 position is converted to the desired functionality by successive conversion to the amide (17), dehydration to the nitrile (18), and finally addition of hydrogen sulfide. There is thus obtained ethionamide (19)... 

After cooling, unreacted ethylenediamine is neutralized in a cooling mixture with the absolute ethanolic hydrochloric acid, filtered off from any components that are insoluble in ethanol and approximately two-thirds of the solvent filtered off under suction in a water jet pump vacuum. Residual quantities of ethylenediamine dihydrochloride are precipitated in fractions by the careful addition of ethyl methyl ketone, after which the imidazoline hydrochloride is separated off by the addition of dry ether. Following repeated recrystallization from ethanol ether, 2-[0(-(2,6-dichlorophenoxy)ethyl] -A -imidazoline hydrochloride is obtained in the form of small white crystals melting at 221°C to 223°C. 

Laminae 4116 +1% Lupersol DDM 5.0% Note Lupersol DDM catalyst is a 60% soln of ethyl methyl ketone peroxide in dimethyl-phthalate. Type II - Sr nitrate 50.0, TeNCbz... 

ProbiMn 12.44 How could mass spectroscopy distinguish among the three deuterated forms of ethyl methyl ketone ... 

Intermolecular hydrogen bonding between a ketone and a hydroxylic solvent such as methanol causes a slight decrease in the absorption frequency of the carbonyl group. For example, a neat sample of ethyl methyl ketone absorbs at 1715 cm-1, whereas a 10% solution of the ketone in methanol absorbs at 1706 cm-1. 

N 13 59% oxygen-rich monomer no props are reported except 1R spectrum was prepd by reaction of ethyl methyl ketone with formaldehyde, hydrogenation of the product with Gi chromite catalyst, acetylation to the triacetate, pyrolysis, deacerylation, and nitration of 3,3"bis(hydroxymethyl) -butene-1. The subject compd was synthesized as a binder constituent, which might be polymer-... 

The obtention of aldehydes can be facilitated by the use of ethyl methyl ketone,74 instead of acetone, due to the lower polarity of the former, leading to a decreased concentration of aldehyde hydrate. 

Alkylpyrazines were then described in a series of papers from Victor Meyer s laboratory at Zurich. Gutknecht (15, 16) examined the reduction of the monoxime of diacetyl (then thought to be a true nitroso derivative of ethyl methyl ketone. 

The synthesis of the 1,3 dione and 1,3 diol was accomplished in an efficient two-step process. Base promoted addition of ethyl methyl ketone to the substituted 1,2,4-triazol-1-yl acetophenone gives the intermediate kinetic aldol product which was reduced using sodium borohydride to the required compound (Figure 24). 

The catalytic transfer reductions of ethyl methyl ketone, isopropyl methyl ketone, and 4-methylacetophenone were studied over the wide series of basic, acidic and semiconducting oxides supported on Si02. Most of them exhibited remarkable activity in the studied transformations. The existence of the strong oxide oxide interaction between deposited phases and Si02 was noted. The nature of catalytic active sites was identified using catalytic titration with Hammett indicators and tetracyanoethylene. An unforeseen modifying effect of n-propylamine, o-nitroaniline, and TCNE onto AI2O3 was observed which led to the enhancement of catalyst activity. 

Optically active a, -epoxy stdfones. - The Darzens reaction of ethyl methyl ketone with chloromethyl / -tolyl sulfone in a two-phase system in the presence of chiral ammonium salts such as N-ethylephedrinium bromide results in a,/3-epoxy sulfones with 0-2.57o optical yields. However, if the supported catalyst (1) is used, optical yields of up to 23% can be obtained as in the example formulated in equation (I). On the other hand, the reaction is slower when the catalyst is supported. The presence of a hydroxy group jS to the nitrogen atom of the catalyst is essential for asymmetric induction. 

Hydrazino-3-methyl-l-phenyluracil added to a soln. of ethyl methyl ketone in tetraline, and refluxed 2-3 hrs. product. Y 95%. F. e., also in ethylene glycol, and isolation of intermediates, s. S. Senda and K. Hirota, Chem. Pharm. Bull. 22,1459 (1974). 

In the case of 3-(2 -thienylidene) camphor 243 chlorosulfonation, under similar conditions, gave the 5 -sulfonyl chloride (sulfonation adjacent to the electron-donating heterosulfur atom). 4-Benzylidenepinocamphorone 244 reacted with excess chlorosulfonic acid (six equivalents) at room temperature (1 week), followed by treatment with thionyl chloride-DMF catalyst, to give the /7-sulfonyl chloride, characterized by formation of sulfonamide deiivatives. 2-Thienylideneacetone 245, together with the benzylidene derivatives of ethyl methyl ketone 246 and diethyl ketone 247, by treatment with excess chlorosul-... 

It is interesting that the action of excess chlorosulfonic acid on the benzylidene derivative of ethyl methyl ketone 246 afforded styrene-4,/3-disulfonyl chloride 240 (Equation 77), the identical compound to that obtained by similar treatment of benzylideneacetone 238 (see p 82). On the other hand, the benzylidene derivative of diethyl ketone 247, under the same conditions, afforded the methylstyrenedisulfonyl chloride 249 (Equation 78). The formation of both products 240 and 249 can be rationalized in terms of the mechanism proposed for the analogous reaction of benzylideneacetone as shown in Scheme 3. 

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