Odorant Octanol

CH3(CH2)4CH(0H)CH2CH3, CgHigO, M, 130.23, bp9i.6 A> 176-176.5 °C 0.8264, Up 1.4252, may occur in its optically active form. It is a colorless liquid that has a mushroomy-earthy odor and occurs in mushrooms. 3-Octanol can be obtained by hydrogenation of 3-octanone it is used in lavender compositions and for imparting mushroom-like odors. 

The Po/w, tbat is, the distribution coefficient between octanol and water, indicates a possible accumulation in fat. Malodorous or odor intense compounds should also be indicated. 

Before the 19th century, perfumers had at their disposal only natural products of plant and animal origin. Today, perfumers work with about 5,000 materials, most of which are produced synthetically. Among the approximately 100 monohydric alcohols used, all chemical types are represented. Several examples of aliphatic alcohols are shown in Figure 5. Nonyl alcohol and 3-octanol are typical fatty alcohols. These alcohols are often found in natural products but are seldom used because of their weak odor. 

Docusate sodium is a white or almost white, waxlike, hitter tasting, plastic solid with a characteristic octanol-like odor. It is hygroscopic and usually available in the form of pellets, flakes, or rolls of tissue-thin material. 

Appearance white amorphous solid with a characteristic octanol-like odor. 

Anthracene is a solid white to yellow crystal, has a weak aromatic odor, and sinks in water. Its characteristics are boiling point, 342°C melting point, 218°C molecular weight, 178.22 density/specific gravity, 1.25 at 27 and 4°C octanol-water coefficient, 4.45. It is soluble in absolute alcohol and organic solvents. Maximum absorption occurs at 218 nm. 

Furfural is a liquid with a pungent almond-like odor. It is found in food items as a natural product. It is soluble in water to the extent of 86 g 1 at room temperature and the log of its octanol/water partition coefficient is 0.41 indicating that it is more soluble in water than in lipophilic solvents. It has a caramel-like taste and boils at 162°C. As a liquid, its density is 1.16 at room temperature but its vapor density is 3.3, causing it to settle in low places during an environmental release. Its odor threshold is somewhere between 0.024 and 20 mg m ... 

PERC is a colorless liquid with an ether-like odor. It boils at 121 °C and has a liquid density of 1.6. It is lipid-soluble with a distribution between octanol/ water of 3.4 and has a solubility of 0.015 g (100 ml) in water. Its vapor density is 5.7 and, consequently, it settles in low areas when released in quantity into the environment. PERC quickly desensitizes the olfactory nervous system but can be recognized in air at 4.7 ppm but is generally thought to have an odor threshold of 50 ppm. A worker may be exposed to high concentrations of PERC without smelling it. 

The relationship between the molecular structure of an aroma compound and its threshold is still unclear. Volatility of a compound may not relate to its threshold. For example, the threshold of ethanol (boiling point is 78°C) is much higher than octanol (boiling point is 195°C) or other homologous alcohol. Ethanol has high volatility but low odor intensity. It is often used as a solvent in compounded flavors. 

Fungi are very adaptable to extreme culture conditions and by changing the culture conditions the production of secondary metabolite can be stimulated or repressed. For example, Lentinus lepidus (Fr.) when cultured on asparagine as the sole nitrogen source produces primarily cinnamic acid derivatives. After three weeks, additional compounds such as the higher alcohols, 1-octanol and 1-decanol appear. However, when cultured on phenylalanine as the sole nitrogen source, it produced a high level of sesquiterpenes, in addition to cinnamates, which resulted in an aromatic-fruity odor(53 ). 

The odor is described as sweet and powerful herbaceous, oily-nutty and warm, milder and not as harsh as that of 2-octanol, much warmer than 1-octanol with moderate to poor tenacity (Arctander, 1967). The flavor is fatty, cheesy, ketonic, mushroom (Chemisis, 1982). 

The analytes used in the evaluation of ring oscillators include octanol and allyl propionate. FigCuPc has a negligible response to both these odorants, whereas the DDa6T is fairly responsive, with the drain current falling in response to both odorants. In this CMOS sensor, upon a 5-sec exposure to octanol, the oscillation... 

Off-white fine powder with a tendency to form easily friable aggregates slight musty odor. Softening begins at 108-117, melting starts at 113-122 and is completed at 144-153. Soly (g/100 ml) at 25 acetone 18.2. DMSO 23.8, distilled water 0.13 (p-isomer), 0.22 (m-isomer), n-heptane 0.04, isopropyl alcohol 14.4, methanol 24.4, methylene chloride 30.0, toluene 3.9. Soly (g/100 g) at 25 xylene < 5, DMF 30. Partition coefficient in n-octanol/water 35 (p-isomer), 66 (m-isomer). LDM In rats, rabbits (mg/kg) > 5000, 4500 orally, > 2000, > 2000 dermally (Hedlund, Anderson). 

Perfumes Odorants include 2-octanol, heptanal, and undecenal... 

White crystal mild odor melts at 42° C (107.6°F) insoluble in water [2 mg/L at 25°C (77°F)] readily soluble in organic solvents octanol-water partition coefficient 50,000. 

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