Obsessive-compulsive disorder genetics

Alsobrook JP 2nd, Zohar AH, Leboyer M, Chabane N, Ebstein RP, Pauls DL (2002) Association between the COM locus and obsessive-compulsive disorder in females but not males. Am J Med Genet 114 116-120... 

Billett EA, Richter MA, Sam F, Swinson RP, Dai XY, King N, Badri F, Sasaki T, Buchanan JA, Kennedy JL (1998) Investigation of dopamine system genes in obsessive-compulsive disorder. Psychiatr Genet 8 163-169... 

Camarena B, Cruz C, de la Puente JR, Nicolini H (1998) A higher frequency of a low activity-related allele of the M AO-A gene in females with obsessive-compulsive disorder. Psychiatr Genet 8 255-257... 

Catalano M, Sciuto G, Di Bella D, Novell E, Nobile M, Bellodi L (1994) Lack of association between obsessive-compulsive disorder and the dopamine D3 receptor gene some preliminary considerations. Am J Med Genet 54 253-255 Cavallini MC, Di Bella D, Pasquale L, Henin M, Bellodi L (1998) 5HT2C CYS23/SER23 polymorphism is not associated with obsessive-compulsive disorder. Psychiatry Res 77 97-104... 

Kinnear C, Niehaus DJ, Seedat S, Moolman-Smook JC, Corfield VA, Malherbe G, Potgieter A, Lombard C, Stein DJ (2001) Obsessive-compulsive disorder and a novel polymorphism adjacent to the oestrogen response element (ERE 6) upstream from the COMT gene. Psychiatr Genet 11 85-87... 

Although genetic influences on the dynamics of drug response have been studied in a wide range of disorders, most of the studies have been carried out in only the past few years. Disorders and behaviors studied include Alzheimer s disease, schizophrenia, depression, suicide, anxiety, obsessive-compulsive disorder (OCD), substance abuse, smoking, and alcoholism. Across these disorders, however, there has been a focus on only a handful of neuroeffector systems. These include apolipoprotein and the cholinergic system (in Alzhei-... 

Obsessive-compulsive disorder is a brain disorder involving the frontal-subcortical circuits. Environmental, genetic, and clinical factors interact in a complex fashion in the individual patient. This chapter will examine OCD from a neurobiological perspective. The characteristics of OCD that are of specific relevance to this topic are listed in Table 12.1. 

Alsobrook, I.J., Leckman, J.F., Goodman, W.K., Rasmussen, S.A., and Pauls, D.L. (1999) Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores. Am J Med Genet 88 669-675. 

Eapen, V., Robertson, M.M., Alsobrook, J.R, 2nd, and Pauls, D.L. (1997) Obsessive compulsive symptoms in Gilles de la Tourette syndrome and obsessive compulsive disorder differences by diagnosis and family history. Am Med Genet 74 432 38. 

Hanna, G.L. (2000) Clinical and family-genetic studies of childhood ohsesslve-compulslve disorder. In Goodman, W.K., Rudorfer, M.V., and Maser, J.D., eds. Obsessive-Compulsive Disorder Contemporary Issues in Treatment. Mahwah, NJ Lawrence Erl-haum Associates, pp. 87-103. 

Karayiorgou, M., Sobin, C., Blundell, M.L., Galke, B.L., Malinova, L., Goldberg, P., Ott, J., and Gogos, J.A. (1999) Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry 45 1178-1189. 

Pauls DL, Towbin KE, Leckman JF, et al Gilles de la Tourette s syndrome and obsessive-compulsive disorder evidence supporting a genetic relationship. Arch Gen Psychiatry 43 1180-1182, 1986... 

Some mental disorders, such as schizophrenia or bipolar illness, may have a higher chance of being expressed in vulnerable individuals as compared with disorders such as depression, anxiety, or obsessive-compulsive disorder, which may more frequently lie dormant in the vulnerable individual (Fig. 4—5). Thus, genetic endowment gives... 

It is uncertain whether, unlike generalized anxiety disorder, panic disorder and obsessive-compulsive disorder, social phobia has a genetic basis. 

Gender in obsessive-compulsive disorder clinical and genetic findings. Eur Neuropsychopharmacol 14 105-113... 

Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D (2006) Serotonin transporter promoter gain-of-fimction genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78 815-826... 

Pato MT, Schindler KM, Pato CN. The genetics of obsessive-compulsive disorder. Curr Psychiatry Rep 2001 3 163-168. 

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