Obsessive-compulsive disorder genetic studies

Although genetic influences on the dynamics of drug response have been studied in a wide range of disorders, most of the studies have been carried out in only the past few years. Disorders and behaviors studied include Alzheimer s disease, schizophrenia, depression, suicide, anxiety, obsessive-compulsive disorder (OCD), substance abuse, smoking, and alcoholism. Across these disorders, however, there has been a focus on only a handful of neuroeffector systems. These include apolipoprotein and the cholinergic system (in Alzhei-... 

Hanna, G.L. (2000) Clinical and family-genetic studies of childhood ohsesslve-compulslve disorder. In Goodman, W.K., Rudorfer, M.V., and Maser, J.D., eds. Obsessive-Compulsive Disorder Contemporary Issues in Treatment. Mahwah, NJ Lawrence Erl-haum Associates, pp. 87-103. 

Karayiorgou, M., Sobin, C., Blundell, M.L., Galke, B.L., Malinova, L., Goldberg, P., Ott, J., and Gogos, J.A. (1999) Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry 45 1178-1189. 

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