Obesity model

An early biphenyl candidate, A-331440 (6) has been reported to be a competitive, potent inverse agonist with balanced activity at human and rat H3Rs with good oral bioavailability [40]. While A-331440 was active in obesity models, its development was precluded by genotoxicity issues [41], The latter was eliminated by a tactical orf/zo-substitution on the phenoxy central core by fluorine to provide A-417022 (7). A-417022 and the 3,5-difluoro analog (A-423579) also produced prolonged weight loss over a 28-day period in a rat diet-induced obesity model [17,41],... 

Nucleotide analysis and predicted amino acid sequence K. S. Cook et ah, Proc. Nat. Acad. Sci. USA 82. 6480 (1985). Structure of adipsin gone H. Y. Min, B. M. Sp/egel man. Nucleic Acids Res. 14, 8879 (1986). I so In front adipose tissue, reportedly the primary site of synthesis and from sciatic nerve K. S. Cook el ah. Science 237, 402 (1987). Studies in murine obesity model and potential biological role J, S. Flier et ah, ibid. 405. 

Matsumoto, K. Y. Watanabe S. Yokoyama. Okara, soybean residue, prevents obesity in a diet-induced murine obesity model. Bosci. Biotech. Bochem. 2007, 71, 121)—111. 

Thiazolidinediones (synonyms glitazones, insulin sensitizers rosiglitazone, pioglitazone) are a novel class of oral antidiabetic drugs that activate the transcription factor peroxisome proliferator-activated receptor (PPARy). Thiazolidinediones ameliorate insulin resistance in obese animal models and in individuals... 

In a mouse model for autoimmune non-obese diabetes (NOD), the full-blown diabetes could be reversed to normoglycaemia by treatment with CD3 antibodies. In these diabetes- tolerant mice, the proportions of CD4+ CD25+ regulatory T cells were increased. Moreover, the CD4+ CD25+ regulatory T cells of the tolerant mice produced high levels of... 

The best-known examples of this approach have been the diabetes/obesity, asthma, and rheumatoid arthritis models created by the firm Entelos. These... 

In addition to the NOD mouse, Entelos has models for several human metabolic diseases (diabetes, obesity, and metabolic syndrome), inflammatory diseases (rheumatoid arthritis), and respiratory diseases (asthma and COPD). 

This model accurately predicted the time curves for blood concentration and urinary excretion of metabolites by male volunteers exposed to 100 ppm trichloroethylene (Sato et al. 1991). It was found that, while the amount of metabolite excretion increases with body weight, the concentration does not, because of a corresponding increase in urinary volume. Also, women and obese people, compared with slim men, have lower concentrations but longer residence times of blood trichloroethylene because of their higher fat content (Sato et al. 1991). As a consequence, the model predicted that 16 hours after exposure to trichloroethylene, one could expect a woman s blood level to be 30% higher and an obese man s level to be twofold higher than that of a slim man (Sato 1993). 

Diabetes insipidus occurs with a loss of vasopressin production in the Brattleboro rat model 330 Mutations and knockouts of peptide-processing enzyme genes cause a myriad of physiological problems 330 Neuropeptides play key roles in appetite regulation and obesity 330 Enkephalin knockout mice reach adulthood and are healthy 331 Neuropeptides are crucial to pain perception 331... 

Katzov, H., Bennet, A.M., Kehoe, P., et al. (2004) A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity. Hutu, Mol Genet., 13, 2647-2657. 

In vivo, FXR is expressed in white adipose tissue (WAT) with levels decreased in the WAT of dietary (high fat) and genetic objob mice) models of obesity. ... 

Metabolism of carbon tetrachloride in obese mice, using three different models impact of differences metabolism on survival. 

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