Nutrient excess

Chronic excessive nutrient intake leads to the deposition of fat, in not only its normal storage site, which is the adipose tissue, but also in liver and skeletal muscle. Nutrient excess also triggers an inflammatory response, with the release of inflammatory cytokines [tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), and CRP]. These inflammatory mediators, along with the intracellular accumulation of lipid metabolites, lead to impaired insulin receptor signaling and defective metabolism in skeletal muscle and liver (37, 38). Nutrient excess also damages cells by generating reactive oxygen species, which results... 

Nutrient excess of some nutrients can cause symptoms similar to those of nutrient... 

Human activity affects parts of the nutrient cycles by removing nutrients from one part of the biosphere and adding them to another. This results in nutrient depletion in one area and nutrient excess in another. This affects water systems, crops, wildlife, and humans. 

Bao J, Scott 1, Lu Z, Pang L, Dimond CC, Gins D, Sack MN (2010) S1RT3 is regulated by nutrient excess and modulates hepatic susceptibiUty to lipotoxicity. Free Radic Biol Med AD, 1230-7. 

Jenkins, M. Y., 1978, Effect of nutrient toxicities (excess) in animals and man vitamin A, "Effect of Nutrient Excesses and Toxicities in Animals and Man," M. Rechcigl, Jr., ed.,... 

Toxic Substances Chemicals and Drugs Constituents of Foods Environmental Pollutants Essential Nutrient Excesses Poisonous Animals and Plants Toxicants from Metabolism Malnutrition... 

Essential Nutrient Excesses. Most well-informed people know that eating too much carbohydrates and/or fat may bring on obesity, and perhaps a host of other ills. However, many of those who take various types of nutritional supplements might be surprised to learn that even excesses of proteins, minerals, and vitamins may be the cause of disorders such as those which follow. 

INTERRELATIONSHIPS. Manganese interacts with other nutrients. Excess calcium and phosphorus interfere with the absorption of manganese the functions of manganese, copper, zinc, and iron may be interchangeable in certain enzyme systems and manganese and vitamin K work together in the promotion of blood clotting. 

Because of the hiuitatious in the NBAL method. Young and Bier have been instrumental in devising a conceptual framework from which to determine optimal protein intakes using stable isotopic tracers. They have coined the terms nutrient deficiency, accommodation, adaptation, and nutrient excess. h7.i48 protein deficiency,... 

---