Drug constituents

Drug/plant source Family Main constituents 

Ginkgo bilobae folium 0.5%- % total fiavonoids (—20 compounds) 

Ginkgo leafs Quercetin, kaempferol and isorhamnetin glycosides  

Ginkgoaceae (1 6) p)-glucoside, quercitrin, isoquercitrin, rutin, k-7-O-gIucoside, k- -O-rutinoside, astragalin, dihydrokaempferol-7-O-gliicoside, isorhamnetin-3-O-rutinoside 

Quercetin-Cj(-rham.nopyTanosyl-4 -0-p)-D-(6 -trans-p-coumaroyl)-glucopyranos ide 

---

It has been known for many years that microbial contaminants may effect the spoilage of pharmaceutical products through chemical, ply sical or aesthetic changes in the nature of the product, thereby rendering it unfit for use (see Chapter 18). Active drug constituents may be metabolized to less potent or chemically inactive forms. Physical changes commonly seen are the breakdown of emulsions, visible surface growth on solids and the formahon of slimes, pellicles or sediments in hquids, sometimes... 

In working with biotechnology-derived drugs, the compoimding pharmacist must be cognizant of both the active drug constituent and the total drug delivery system or... 

The absorbance measured with a base line at 3300 cm-l or 3 70 cm-l. The calibration curves were linear in the concentration range between 0-5 to 2 mg/ml and the results were in good agreement with those determined colorimetrically. The determination was not interferred with the coexistance of a limited amount of 1 0 possible drug constituents e.g., phenacetin and pyrabital (1 1 ). 

Thus, pure adhyperforin has been found to have the same inhibitorial potency as hyperforin on the uptake of monoamine neurotransmitters [86], and more polar drug constituents such as flavonoid glycosides and procyanidins [3,87,90] have also been shown to be effective in behavioral models of depression. 

Changes in stability of the drug constituent when delivered by the device or when used as a coating on the device... 

Changes in the stability or activity of a drug constituent when used together with an energy emitting device... 

In the appendix of Volumes 1 and 2 (p. 451/1009), the most used reagents and basic solvent systems in TLC and HPLC are listed for the detection of main structure types of drug constituents in herbal drugs. 

Shibata S 1981 Chinese drug constituents isolation of the biologically active principles. In Natori S, Ikekawa N, Suzuki M (eds) Advances in natural products chemistry. Kodansha Tokyo, 398-416... 

Toxic Substances Chemicals and Drugs Constituents of Foods Environmental Pollutants Essential Nutrient Excesses Poisonous Animals and Plants Toxicants from Metabolism Malnutrition... 

---