Nucleosome assembly and remodeling

In addition to a potential role of HMGB proteins in nucleosome assembly, it has recently become apparent that many chromatin remodeling complexes either contain, or can associate with, a polypeptide containing an HMG-box homologous to the HMGBl B domain (Table 2). Examples of such complexes include the BAF (a mammalian SWI/SNF related complex [106]) and the Drosophila BRM (brahma) [Pg.115]

Complex No. of components HMG domain components) Reference Comments [Pg.116]

SET (human) 4 HMGB2 100 DNA repair function, possibly more components in active complex [Pg.116]

BRM (Drosophila) 7 BAPlll 107 BAPlll has homologies with BAF57 outside the HMG box [Pg.116]

CHDl (Drosophila) SSRPl 113 Colocalisation of CHDl and SSRPl on polytene chromosomes [Pg.116]

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