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Chromatin-remodeling complexes

Chromatin is composed of nucleosomes, where each comprise 147 base pairs of DNA wrapped around an octamer oftwo copies of each histone H2A, H2B, H3, and H4. Nucleosomes are folded into higher-order structures that are stabilized by linker histones. Chromatin structure can be altered by enzymes that posttranslationally modify histones (e.g., through phosphorylation, acetylation, methylation, or ubiquitination) or by ATP-driven chromatin-remodeling complexes that alter nucleosome position and/or composition. [Pg.362]

Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E (2006) The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol... [Pg.114]

Treand C, du Chene I, Bres V, Kieman R, Benarous R, Benkirane M, Emdiani S (2006) Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter. EMBO J 25(8) 1690-1699... [Pg.117]

Eisen JA, Sweder KS, Hanawalt PC (1995) Evolution of the SNF2 family of proteins subfamilies with distinct sequences and functions. Nucleic Acids Res 23 2715-2723 Falbo KB, Shen X (2006) Chromatin remodeling in DNA replication. J Cell Biochem 97 684-689 Fazzio TG, Gelbart ME, Tsukiyama T (2005) Two distinct mechanisms of chromatin interaction by the Isw2 chromatin remodeling complex in vivo. Mol Cell Biol 25 9165-9174... [Pg.41]

Figure 1. Schematics of the effect of mH2A on transcription, (a) The mobiUzation of conventional promoter nucleosome by the chromatin remodeling complex generated a nucleosome-free promoter, which allowed the binding of the transcription factors and transcription to proceed, (b) MacroH2A nucleosome cannot be mobilized by die chromatin remodeling complex and die transcriptions factors are unable to bind macroH2A nucleosome containing promoter, which results in inhibition of the initiation of transcription. (See Colour Plate 8.)... Figure 1. Schematics of the effect of mH2A on transcription, (a) The mobiUzation of conventional promoter nucleosome by the chromatin remodeling complex generated a nucleosome-free promoter, which allowed the binding of the transcription factors and transcription to proceed, (b) MacroH2A nucleosome cannot be mobilized by die chromatin remodeling complex and die transcriptions factors are unable to bind macroH2A nucleosome containing promoter, which results in inhibition of the initiation of transcription. (See Colour Plate 8.)...
In yeast, H2A.X is dephosphorylated by the phosphatase PPH3p after it has been released from chromatin. The release of y-H2A.X from repaired chromatin is independent of DNA replication, and it therefore must be assumed that a chromatin remodeling complex actively exchanges 7-H2A.X from nucleosomes. Thus far, several candidate remodeling complexes have been identified that specifically target nucleosomes containing 7-H2A.X. [Pg.101]

In addition to a potential role of HMGB proteins in nucleosome assembly, it has recently become apparent that many chromatin remodeling complexes either contain, or can associate with, a polypeptide containing an HMG-box homologous to the HMGBl B domain (Table 2). Examples of such complexes include the BAF (a mammalian SWI/SNF related complex [106]) and the Drosophila BRM (brahma)... [Pg.115]

Moreira, J.M. and Holmberg, S. (1999) Transcriptional repression of the yeast CHAl gene requires the chromatin-remodeling complex RSC. EMBO I. 18, 2836-2844. [Pg.130]

Subunit composition and functions of chromatin remodeling complexes... [Pg.423]

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See also in sourсe #XX -- [ Pg.242 , Pg.245 , Pg.249 , Pg.267 ]

See also in sourсe #XX -- [ Pg.43 ]



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Chromatin

Chromatin remodeling

Chromatin-remodeling complexes recruitment

Remodel

Remodelling

Remodelling complex

Swi / Snf chromatin-remodeling complex

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