Molecular structure nucleic acids

Wilkins, M.H.F., Stokes, A.R., Wilson, H.R. Molecular structure of nucleic acids. Molecular structure of deoxypentose nucleic acids. Nature 171 738-740,... 

Watson, J.D., Crick, F.H.C. Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. Nature 171 737-738, 1953. 

This chapter describes the chemistry of nucleotides and the m or classes of nucleic acids. Chapter 12 presents methods for determination of nucleic acid primary structure (nucleic acid sequencing) and describes the higher orders of nucleic acid structure. Chapter 13 introduces the molecular biology of recombinant DNA the construction and uses of novel DNA molecules assembled by combining segments from other DNA molecules. 

For molecular sizes that are amenable by NMR techniques, nucleic acids usually lack a tertiary fold. This fact, together with the characteristic low proton density, complicates NMR structural analysis of nucleic acids. As a result, local geometries and overall shapes of nucleic acids, whose structures have been determined by NMR, usually are poorly defined. Dipolar couplings provide the necessary long-range information to improve the quality of nucleic acid structures substantially [72]. Some examples can be found already in the literature where the successful application of dipolar couplings into structure calculation and structure refinement of DNA and RNA are reported [73-77]. 

James D. Watson (1928-) and Francis H. C. Crick (1916- ) publish two landmark papers in the journal Nature. The papers are entitled Molecular structure of nucleic acids a structure for deoxyribose nucleic acid and Genetic implications of the structure of deoxyribonucleic acid. Watson and Crick propose a double helical model for DNA and call attention to the genetic implications of their model. Their model is based, in part, on the x-ray crystallographic work of Rosalind Franklin (1920-1958) and the biochemical work of Erwin Chargaff (1905- ). Their model explains how the genetic material is transmitted. 

J. D. Watson, F. H. C. Crick, Molecular Structure of Nucleic Acids A Structure for Deoxyribose Nucleic Acid. Nature 1953, 171, 737-738. 

Watson, J. D. and F. H. C. Crick 1953a. Molecular stmcture of nucleic acids A structure for desoxyribonucleic acids. Nature 171 731... 

Watson J. and Crick F. (1953). Molecular structure of nucleic acids a structure for deoxyribonucleic acid. Nature 117 737-738. 

Since the 1953 paper by Watson and Crick on a structure for desoxyribose nucleic acid, the structural and functional importance of base pairs linked by hydrogen bonds (H-bonds) is one of the central themes of molecular and... 

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