Structure nucleic acids

Saenger, W. Prinsiples of nucleic acid structure. Springer-Verlag, Berlin (1984) 584... 

W Saenger. Principles of Nucleic Acid Structure. New York Sprmger-Verlag, 1984. 

This chapter describes the chemistry of nucleotides and the m or classes of nucleic acids. Chapter 12 presents methods for determination of nucleic acid primary structure (nucleic acid sequencing) and describes the higher orders of nucleic acid structure. Chapter 13 introduces the molecular biology of recombinant DNA the construction and uses of novel DNA molecules assembled by combining segments from other DNA molecules. 

FIGURE 11.18 Furanoses are represented by lines phosphodiesters are represented by diagonal slashes in this shorthand notation for nucleic acid structures. 

D-Ribose Nucleic acids. Structural elements of nucleic acids and coenzymes, eg, ATP, NAD, NADP, flavo-proteins. Ribose phosphates are intermediates in pentose phosphate pathway. ... 

Interaction of Protoberberine Alkaloids with Nucleic Acid Structures. . . 176... 

Keywords Berberine Palmatine Coralyne Polymorphic nucleic acid structures Alkaloid-nucleic acid interactions... 

This technique provides an easy and convenient method to evaluate the association of small molecules to various polymorphic forms of nucleic acid structures from the measurement of absorbance changes in the absorption maximum of the hgand, where the nucleic acid has no absorbance. Information about overall DNA/RNA base preference and nature of binding can also... 

Saenger W (1984) Principles of nucleic acid structure. Springer, Berlin Heidelberg... 

Das S (2000) Biophysical studies on the interaction of benzophenanthridine alkaloids with polymorphic nucleic acid structures. PhD Thesis, Jadavpim University... 

Very recently the trans- [Pt(NH3)2Cl2] isomer has been shown to promote the formation of some highly unusual multiple strand nucleic acid structures (28). A parallel-stranded DNA duplex, psPtDNA, has been prepared which incorporates a frarcs-Pt(NH3)2+ crosslink. The pla-tinated strands were synthesized through the series of reactions illustrated in Fig. 3. The initial mono-functional G N7 adduct is formed at pH 3.5 by addition of rans-[Pt(NH3)2(H20)Cl]+ to the pyrimidine-rich sequence 5 -d(T4CT4G). After the pH is increased, normal anti-parallel duplex formation occurs upon addition of the complementary purine-rich strand, 5 -d(A4GA4G). This intermediate anti-parallel stranded... 

Williams LD (2005) Between Objectivity and Whim Nucleic Acid Structural Biology. 253 77-88... 

Fig. 10 Charge transport is observed in a variety of nucleic acid assemblies over a wide distance regime (3.4-200 A). Shown are examples of nucleic acid structures through which charge transport has been examined a B-form DNA b DNA-RNA hybrids c cross-over junctions and d nucleosome core particles. In all assemblies, the charge transport chemistry is extremely sensitive to the structure of the -stacked nucleic acid bases...

Bloomfield VA, Crothers DM, Tinoco JI (1999) Nucleic Acids Structure, Properties, and Function. University Science Books, Sausalito... 

A comprehensive series of mono- and dinuclear iodoplatinum(II) complexes [Ptl(dien)]+ and [ PtI(dien) 2(/r-CH2) ] (42) (dien = parent or substituted diethylenetriamine n = 2-9), respectively, have been synthesized as potential probes of nucleic acid structure.158 Both chiral and achiral species were prepared. In general, the complexes are synthesized by the reaction of trans-[PtI2(DMSO)2] with the dien ligand in DMF solution. 

Bloomfield, V. A., D. M. Crothers, I. Tinoco, and J. Hearst (2000), Nucleic Acids Structures, Properties and Functions, University Science Books, Sausalito, CA. 

Acridine and its derivatives are also fused nitrogen heterocycles similar to acridones, which display a high fluorescence quantum yield and possess the ability to intercalate tightly, though reversively, to the DNA helical structure [73], with large binding constants [74]. As a result, acridine dyes are recognized in the field of the development of probes for nucleic acid structure and conformational determination [75-77]. 

Schoning, K-V., Scholz, P., Guntha X. Vu, Krischnamurthy, R. and Eschenmoser, A. (2000). Chemical etiology of nucleic acid structure. Science, 290, 1347-1351... 

Saenger, W. "Principles of Nucleic Acid Structure." Springer-Verlag New York, 1984. 

Several mathematical techniques have been used to obtain atomic coordinates for nucleic acid structures. They incorporate several different approaches. (a) Systematic rotations about all backbone torsional angles are performed and those conformations which form helicies and have adjacent bases parallel or in a given orientation are selected (59 6o). (b) Least squares techniques are used to re-... 

Cimino, C.P., Camper, H.B., Isaacs, S.T., and Hearst, J.E. (1985) Psoralens as photoactive probes of nucleic acid structure and function Organic chemistry, photochemistry, and biochemistry. Annu. Rev. Biochem. 54, 1151-1193. 

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