Nucleic acid components

Ruonne Substituted Analogs of Nucleic Acid Components Bergstrom, D E, Swartlmg, D J Mol Struct Energ S 250-306 133 o 2... 

The following biochemically related F-NMR studies ot structure or tunebon have been published nucleic acid components (mainly 5-fluorouracil) [86... 

The 8-aza analogs of purine bases were the first to be studied among all the aza analogs of nucleic acid bases (as early as 1945). Before that time the chemistry of these substances had not been treated in detail from any aspect. Thus the entire chemistry of the u-triazolo [4,5-d]pyrimidines was developed only in connection with the study of antimetabolites of nucleic acid components. Therefore all the papers involved are largely of preparative character and only rarely discuss. theoretical points. 

In addition to the nucleic acids themselves, nucleic acid derivatives such as ATP are involved as phosphorylating agents in many biochemical pathways, and several important coenzymes, including NAD+, PAD, anti coenzvme A, have nucleic acid components. 

The examples just presented give initial impressions of how DNA can be utilized as a template in the synthesis of nanometric and mesoscopic aggregates. However, the studies emphasize the importance of fundamental research on the interaction between DNA and the various binders, such as metal and organic cations. Of particular importance are the consequences of binding events on the structure and topology of the nucleic acid components involved. 

Ion exchange chromatography has also been extensively applied to the analysis of nucleic acid components (3,14,35),... 

Basiuk, V. A. and Chuko, A. A., Selectivity of bonded stationary phases containing uracil derivatives for liquid chromatography of nucleic acid components, /. Chromatogr. Sci., 31, 120, 1993. 

We have now adjusted our molecular systems to provide a model in which both forces can operate simultaneously. The U-shaped relationship that exists between the imide function and amides of aryl amines creates a hydrogen bonding edge and a planar stacking surface that converge from perpendicular directions as in 44 to provide a microenvironment complementary to nucleic acid components. A large number of aromatic rings can be functionalized with this simple scaffold, and spacers (R) can also be incorporated. The imide function is a mimic of the thymine residues. 

Koglin E., Sequaris J.M., Valenta P., Surface Raman-spectra of nucleic-acid components adsorbed at a silver electrode, J. Molecular Struct. 1980 60 421-425. 

Weith, H.L., Wiebers, J.L., and Gilham, P.T. (1970) Synthesis of cellulose derivatives containing the dihy-droxyboryl group and a study of their capacity to form specific complexes with sugars and nucleic acid components. Biochemistry 9, 4396-4401. 

P. Roy-Burman, Analogues of Nucleic Acid Components/ Springer-Verlag, New York, 1970. 

Over thirty publications resulted from Tipson s work in Levene s laboratory. Along with the work on nucleic acid components, he also studied the structures of gum arabic and other plant gums, and conducted a range of synthetic investigations on sugars, with particular emphasis on uronic acids and 5-carbon ketoses. His 1939 observation that acetylated glycosyl halides... 

The genetic information of eukaryotic cells is propagated in the form of chromosomal DNA. Besides the nucleic acid component, chromosomes contain architectural proteins as stoichiometric components, which are involved in the protective compaction of the fragile DNA double strands. Together, the DNA and proteins form a nucleoprotein structure called chromatin. The fundamental repeating unit of chromatin is the nucleosome core particle. It consists of about 147 base pairs of DNA wrapped around a histone octamer of a (H3/H4)2 tetramer and two (H2A-H2B) heterodimers. One molecule of the linker histone HI (or H5) binds the linker DNA region between two nucleosome core particles (Bates and Thomas 1981). 

The major intermediates in the biosynthesis of nucleic acid components are the mononucleotides uridine monophosphate (UMP) in the pyrimidine series and inosine monophosphate (IMP, base hypoxanthine) in the purines. The synthetic pathways for pyrimidines and purines are fundamentally different. For the pyrimidines, the pyrimidine ring is first constructed and then linked to ribose 5 -phosphate to form a nucleotide. By contrast, synthesis of the purines starts directly from ribose 5 -phosphate. The ring is then built up step by step on this carrier molecule. 

Later on we succeeded in partially aligning microcrystals within the sample they were placed in X-ray capillaries and pulled down by gently sucking their mother liquor, whereupon the needle-shaped crystals oriented along the capillary axis. Such samples sometimes, but only under perfect measuring conditions, produced pseudo fiber patterns which consisted of oriented arcs with average length of 60° (Fig. lb). In many cases these arcs were comj sed of distinct spots that could be clearly resolved by eye. Since such patterns may arise from partial orientation of the nucleic acid component within fairly well packed particles, these patterns indicated reasonable internal order. 

Guanine is a preferential DNA target to several oxidants it shows the lowest ionization potential among the different purine and pyrimidine nucleobases and it is the only nucleic acid component that exhibits significant reactivity toward singlet oxygen ( O2) at neutral pH. ... 

Neilands O (2001) Dioxo-and aminooxopyrimido-fused tetrathiafulvalenes-base compounds for novel organic semiconductors and for design of sensors for recognition of nucleic acid components. Mol Cryst Liq Cryst 355 331-349... 

DiPaolo, J.A. (1952) Studies on chemical mutagenesis utilizing nucleic acid components, urethane, and hydrogen peroxide.. im. Natural., 86, 49-55... 

Fluorine-Substituted Analogs of Nucleic Acid Components ... 

Catterall H, Davies MJ, Gilbert BC (1992) An EPR study of the transfer of radical-induced damage from the base to sugar in nucleic acid components relevance to the occurrence of strand-breakage. J Chem Soc Perkin Trans 2 1379-1385... 

Michaels HB, Rasburn EJ, Hunt JW (1976) Interaction of the radiosensitizer para-nitroacetophenone with radiation-induced radicals on nucleic acid components. Radiat Res 65 250-267 Mieden OJ, Schuchmann MN, von Sonntag C (1993) Peptide peroxyl radicals base-induced O2 elimination versus bimolecular decay. A pulse radiolysis and product study. J Phys Chem 97 3783-3790... 

Cadet J, Voituriez L, Berger M (1983) Separation of nucleic acid components and their radiation-induced degradation products on chemically bonded C12 reversed-phase thin-layer plates. J Chromatogr 259 111-119... 

N. K. Kochetkov, V. N. Shibaev, and A. A. Kost, Modification of nucleic acid components with a-halo aldehydes, Dokl. Akad. Nauk SSSR, 205 (1972) 100-103. 

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