Components of Nucleic Acids

Ruonne Substituted Analogs of Nucleic Acid Components Bergstrom, D E, Swartlmg, D J Mol Struct Energ S 250-306 133 o 2... 

The 8-aza analogs of purine bases were the first to be studied among all the aza analogs of nucleic acid bases (as early as 1945). Before that time the chemistry of these substances had not been treated in detail from any aspect. Thus the entire chemistry of the u-triazolo [4,5-d]pyrimidines was developed only in connection with the study of antimetabolites of nucleic acid components. Therefore all the papers involved are largely of preparative character and only rarely discuss. theoretical points. 

Ion exchange chromatography has also been extensively applied to the analysis of nucleic acid components (3,14,35),... 

Basiuk, V. A. and Chuko, A. A., Selectivity of bonded stationary phases containing uracil derivatives for liquid chromatography of nucleic acid components, /. Chromatogr. Sci., 31, 120, 1993. 

Koglin E., Sequaris J.M., Valenta P., Surface Raman-spectra of nucleic-acid components adsorbed at a silver electrode, J. Molecular Struct. 1980 60 421-425. 

P. Roy-Burman, Analogues of Nucleic Acid Components/ Springer-Verlag, New York, 1970. 

The major intermediates in the biosynthesis of nucleic acid components are the mononucleotides uridine monophosphate (UMP) in the pyrimidine series and inosine monophosphate (IMP, base hypoxanthine) in the purines. The synthetic pathways for pyrimidines and purines are fundamentally different. For the pyrimidines, the pyrimidine ring is first constructed and then linked to ribose 5 -phosphate to form a nucleotide. By contrast, synthesis of the purines starts directly from ribose 5 -phosphate. The ring is then built up step by step on this carrier molecule. 

Neilands O (2001) Dioxo-and aminooxopyrimido-fused tetrathiafulvalenes-base compounds for novel organic semiconductors and for design of sensors for recognition of nucleic acid components. Mol Cryst Liq Cryst 355 331-349... 

Fluorine-Substituted Analogs of Nucleic Acid Components ... 

Cadet J, Voituriez L, Berger M (1983) Separation of nucleic acid components and their radiation-induced degradation products on chemically bonded C12 reversed-phase thin-layer plates. J Chromatogr 259 111-119... 

N. K. Kochetkov, V. N. Shibaev, and A. A. Kost, Modification of nucleic acid components with a-halo aldehydes, Dokl. Akad. Nauk SSSR, 205 (1972) 100-103. 

The topic of this review is the excited-state structural dynamics of nucleic acids and their components. As stated above, the excited states of nucleic acid components... 

With this normal mode description, then, it is instructive to review the resonance Raman intensity-derived excited-state structural dynamics. The first UV resonance Raman study of thymine was not done until 1994 by Lagant, et al. [113], Although Raman and IR spectra of thymine had been recorded much earlier. Most earlier studies of nucleic acid components focussed on the nucleosides and nucleotides. Indeed, much of the earlier research on nucleic acid components was done by the groups of Peticolas and Spiro, working independently. Spiro focussed more on nucleosides and larger nucleic acid structures (see below), while Peticolas examined the nucleobases initially. Peticolas s approach was to combine ab initio computations of the ground-state and excited-state structures and vibrational frequencies, with... 

What is remarkable is that all of these early measurements of the UV resonance Raman spectra of nucleic acid components involved computational and theoretical support to their experimental findings. For example, Spiro used CINDO calculations to determine the nature of the excited electronic states of the nucleotides [157], In the early and mid 1970 s, many researchers were also attempting to understand resonance Raman spectroscopy, the types of information it could provide, and a unifying theoretical framework to the intensities [147, 159-172], UV resonance Raman spectra provided some of the first experimental evidence to test the various theoretical models. Peticolas attempted to fit the observed experimental excitation profiles of AMP [156], UMP [151, 154] and CMP [152, 153] to the sum-over-states model for the resonance Raman cross-sections. From these simulations, they were able to obtain preliminary excited-state structural dynamics of the nucleobase chromophores of the nucleotides for UMP [151, 153, 158] and CMP [153], For AMP, the experimental excitation profiles were simulated with an A-term expression, but the excited-state structural changes were not obtained. Rather, the goal of that work was to identify the electronic transitions within the lowest-energy absorption band of adenine [156],... 

Becker RS, Kogan G (1980) Photophysical properties of nucleic acid components. 1. The pyrimidines Thymine, uracil, N,N-dimethyl derivatives, and thymidine. Photochemistry and Photobiology 31 5-13. 

Jeffrey GA (1989) Hydrogen bonding in crystal structures of nucleic acid components purines, pyrimidines, nucleosides and nucleotides. In Saenger W (ed), Landolt-BOrnstein. Numerical Data and Functional Relationships in Science and Technology. New Series, Group VII, Vol. Ib. Springer, Berlin, pp 277-348... 

Improvements in column technology, detector sensitivity and the development of new detection systems, have made possible the routine separation of picomole quantities of nucleic acid components in complex physiological matrices. The very sensitivity of most LC systems, however, which is invaluable in the analysis of biological samples, is often the limiting factor because of inadequate or ambiguous identification methods. Although tremendous advances have been made in the on-line combination of HPLC with spectroscopic techniques [e.g., mass spectrometry, Fourier transform infrared (FT/IR), nuclear magnetic resonance], their application has not become routine in most biochemical and biomedical laboratories. 

Immunogens Prepared by Covalent Linkage of Nucleic Acid Components to Proteins... 

Secondary effects in gel filtration columns (cf. Schwartz and Zabin 1966) allow some fractionation of nucleic acid components, particularly nucleosides, on these columns (Hohn and Pollman 1963 Schwartz et al. 1965 Uziel and Cohn 1965 Mezzasoma and Farina 1966a, b Braun 1967a, b Dirheimer and Ebel 1967 Hohn and Schaffer 1967 Carrara and Bernard 1968a). 

The fluorescence of nucleic acids and of nucleic acid components (e.g. of the bases) is difficult to be measured at room temperature and at neutral pH, since the fluorescence quantum yield lies in the range 10-4 to 10-5. 

Roy-Burman, P. Analogues of nucleic acid components, pp. 62-64. Berlin - Heidelberg - New York Springer 1970. 

Pyrazole derivatives as analogues of nucleic acid components 84MI5. Pyrazole derivatives as antiinflammatory agents 8OMI5. 

Amino-l-ribosylimidazole-4-carboxamide, cyclization of 78JHC353. Imidazole analogues of nucleic acid components 84MI5. Imidazole-bridged bimetallic center in Cu Zn superoxide dismutase and its... 

Thiazole analogues of nucleic acid components 84MI5. 

Since the reviews by Tipson < > and Barker < > on the chemistry of the nucleic acids, two Chapters have appeared in these Volumes on the chemistry of nucleic acid components, namely, the pyrimidine and purine ... 

THFs or structural analogues thereof (methanopterin) are universally required for the maintenance of Cl metabolism. Cl synthones play an indispensable role for the biosynthesis of nucleic acid components and of methionine. Even when eubacteria are supplied with exogenous sources of all metabolites whose biosynthesis requires folate-type cofactors, they require the coenzyme for the initiation of protein biosynthesis. 

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