Nuclear receptor Classification

Table 11.1 Nuclear receptor classification based on sequence homology.

In line with the situation found previously for the other receptor families, several classification schemes coexist for nuclear receptors. In particular, beyond the NC-IUPHAR system described above, an alternative nomenclature system has been proposed and is currently widely accepted and used by the research community working in this family. This annotation scheme consists of a 3-character code. The first character is a number that designates... 

Under this framework. Fig. 6 shows the basic pieces for constructing annotated chemical libraries. On the one hand, proteins should be stored using the appropriate annotation under their respective protein-family classification schemes (in this case, nuclear receptors). On the other hand, molecules should be stored using a unique hierarchical identifier. The link between the two entities (molecules and proteins) would be defined by pharmacological data (activity). The use of a certain criteria would then allow to construct a binary annotation matrix, from which the mapping of the chemogenomic space is established. 

The nuclear receptor superfamily can be generally divided into four major subfamilies based on their DNA-binding properties and dimerization preferences. However, this classification is rather broad and does not take into account of any evolutionary relationship between nuclear receptors. Therefore, a new phylogeny-based nomenclature approved by the Nuclear Receptor Nomenclature... 

Novae, N. and Heinzel, T. (2004) Nuclear receptors overview and classification. Current Drug Targets - Inflammation and Allergy, 3, 335-346. 

Today, we realize that drug binding/receptor sites that produce pharmacological effects may be part of any cellular constituent for example, nuclear DNA, mitochondrial enzymes, ribosomal RNA, cytosolic components, and cell membranes and wall, to name the most obvious. Nevertheless, in contemporary pharmacology, some authors and researchers apply a more restricted use of the term receptor, reserving it for protein complexes embedded in, and spanning, cellular membranes. However, exceptions to this classification system clearly exist. For example, steroids are known to interact with cytosolic receptors that transport them into the nucleus (their site of... 

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