Nuclear magnetic resonance spectroscopy principle

Duer MJ (ed) (2002) Solid-state nuclear magnetic resonance spectroscopy, principles and applications. Blackwell Science, Oxford... 

Johnson CS Jr. (1999) Diffusion ordered nuclear magnetic resonance spectroscopy Principles and applications. Progress in NMR Spectroscopy 34 203. 

See also. Nuclear Magnetic Resonance Spectroscopy Principles. Nuclear Magnetic Resonance Spectroscopy-Applicable Elements Carbon-13 Nitrogen-15. Nuclear Magnetic Resonance Spectroscopy Applications Pharmaceutical. Peptides. Structural Elucidation. 

See alsor. Conductimetry and Oscillometry. Coulometry. Distillation. Gas Chromatography Overview. Gravimetry. Infrared Spectroscopy Overview Near-Infrared. Ion Exchange Ion Chromatography Applications. Mass Spectrometry Overview. Microwave Spectroscopy. Nuclear Magnetic Resonance Spectroscopy Principles. Titrimetry Potentiometric. 

Finally, Burkhard Luy, Andreas Frank and Horst Kessler discuss Conformational Analysis of Drugs by Nuclear Magnetic Resonance Spectroscopy . The determination and refinement of molecular conformations comprehends three main methods distance geometry (DG), molecular dynamics (MD) and simulated anneahng (SA). In principle, it is possible to exclusively make use of DG, MD or... 

R.K. Harris, Nuclear Magnetic Resonance Spectroscopy Chapter 6, Longmans, 1997 C.A. Fyfe, Solid State NMR for Chemists, C.F.C. Press, 1983 M.J. Duer, Introduction to Solid-State NMR Spectroscopy, Black-well Science, London, 2004 M.J. Duer, Solid-State NMR Spectroscopy Principles and Applications, Blackwell Science, London, 2002. 

H. Noth, B. Wrackmeyer, Nuclear Magnetic Resonance Spectroscopy of Boron Compounds, in NMR - Basic Principles and Progress, P. Diehl, E. Fluck, R. Kosfeld, eds., Vol. 14, Springer Verlag, Berlin-Heidelberg-New York, 1978. 

Fourier transform methods have revolutionized many fields in physics and chemistry, and applications of the technique are to be found in such diverse areas as radio astronomy [52], nuclear magnetic resonance spectroscopy [53], mass spectroscopy [54], and optical absorption/emission spectroscopy from the far-infrared to the ultraviolet [55-57]. These applications are reviewed in several excellent sources [1, 54,58], and this section simply aims to describe the fundamental principles of FTIR spectroscopy. A more theoretical development of Fourier transform techniques is given in several texts [59-61], and the interested reader is referred to these for details. 

The aim of this text is to introduce the fascinating topic of the hyphenation of chromatographic separation techniques with nuclear magnetic resonance spectroscopy to an interested readership with a background either in organic, pharmaceutical or medical chemistry. The basic principles of NMR spectroscopy, as well as those of separation science, should previously be known to the reader. 

This article treats the benefits, possibilities and drawbacks of supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE) coupled to nuclear magnetic resonance spectroscopy. After a general overview and consideration of the motivation for such techniques, the design of high-pressure flow probes, as well as the principle experimental set-ups, are described. By means of several applications and comparison to HPLC-NMR, the utility of these hyphenated techniques is demonstrated. 

Lambert, J.B., Holland, L.N., and Mazzola, E.P., Nuclear Magnetic Resonance Spectroscopy Introduction to Principles, Applications and Experimental Methods, Prentice Hall, Englewood Cliffs, NJ, 2003. 

B. Luy, A. O. Frank and H. Kessler, Conformational analysis of drugs by nuclear magnetic resonance spectroscopy, in Methods and Principles in Medicinal Chemistry, R. Mannhold, H. Kubinyi and G. Folkers, eds., Vol. 37, Wiley-VCH, Weinheim, 2008, p. 207. 

After a short qualitative introduction to the principles of dynamic nuclear magnetic resonance spectroscopy , the proposed interconversion processes for cycloheptanes and cycloheptenes are explained in detail. According to calculations, the most favourable conformation for cycloheptanes seems to be the twist chair cycloheptenes prefer the chair form. Possible conformational processes for chair and boat forms are discussed and illustrated. 

Several classic books in NMR, which are now out of date overall, are still authoritative in specific areas. For example, Principles of Nuclear Magnetism by Ana-tole Abragam,33 High Resolution Nuclear Magnetic Resonance by J. A. Pople, W. G. Schneider, and H. J. Bernstein,34 and High Resolution Nuclear Magnetic Resonance Spectroscopy by J. W. Emsley, J. Feeney, and L. H. Sutcliffe35 are the sources for much material presented in this and other NMR books. 

I. Principles of Nuclear Magnetic Resonance Spectroscopy (Sections 13.1 - 13.3). 

There are various kinds of spectroscopy visible and ultraviolet (UV) absorption spectroscopy, Raman and infrared spectroscopy, nuclear magnetic resonance spectroscopy, and electron-spin resonance (ESR) spectroscopy. A brief description of the principles of these techniques and their application to the study of ions in solution follows (see also Section 2.11). 

B-1978MI417-01 H. Noth and B. Wrackmeyer Nuclear magnetic resonance spectroscopy of boron compounds, in NMR- Basic Principles... 

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