Diffusion-ordered nuclear magnetic resonance

Johnson CS Jr. (1999) Diffusion ordered nuclear magnetic resonance spectroscopy Principles and applications. Progress in NMR Spectroscopy 34 203. 

Several mechanisms are involved in the permeability through Caco-2 cells. In order to obtain a more pure measure of membrane permeability, an experimental method based on ghost erythrocytes (red blood cells which have been emptied of their intracellular content) and diffusion constant measurements using nuclear magnetic resonance (NMR) has been proposed [108]. 

Abstract We use Nuclear Magnetic Resonance relaxometry (i.e. the frequency variation of the NMR relaxation rates) of quadrupolar nucleus ( Na) and H Pulsed Gradient Spin Echo NMR to determine the mobility of the counterions and the water molecules within aqueous dispersions of clays. The local ordering of isotropic dilute clay dispersions is investigated by NMR relaxometry. In contrast, the NMR spectra of the quadrupolar nucleus and the anisotropy of the water self-diffusion tensor clearly exhibit the occurrence of nematic ordering in dense aqueous dispersions. Multi-scale numerical models exploiting molecular orbital quantum calculations, Grand Canonical Monte Carlo simulations, Molecular and Brownian Dynamics are used to interpret the measured water mobility and the ionic quadrupolar relaxation measurements. 

DOSY NMR 2-dimensional diffusion ordered spectroscopy nuclear magnetic resonance (spectroscopy) dpb bis(dibenzylideneacetone) dppe 1,2-bis(diphenylphosphino)ethane DSC differential scanning calorimetry DV differential viscometry... 

Solid-state nuclear magnetic resonance (NMR) has been extensively used to assess structural properties, electronic parameters and diffusion behavior of the hydride phases of numerous metals and alloys using mostly transient NMR techniques or low-resolution spectroscopy [3]. The NMR relaxation times are extremely useful to assess various diffusion processes over very wide ranges of hydrogen mobility in crystalline and amorphous phases [3]. In addition, several borohydrides [4-6] and alanates [7-11] have also been characterized by these conventional solid-state NMR methods over the years where most attention was on rotation dynamics of the BHT, A1H4, and AlHe anions detection of order-disorder phase transitions or thermal decomposition. There has been little indication of fast long-range diffusion behavior in any complex hydride studied by NMR to date [4-11]. 

Various new techniques suitable for estimating D are now available fluorescence correlation spectroscopy (FCS) [5], fluorescence recovery after photobleaching (FRAP) [6], pulsed field gradient nuclear magnetic resonance (PFG-NMR) [7], diffusion ordered NMR spectroscopy (DOSY) [8], and others. Among these, FCS and FRAP are popular in biological studies because they are often installed on a commercial LSM system and conveniently coupled with it. 

KF Morris, CS Johnson Jr. Diffusion-ordered two-dimensional nuclear magnetic resonance spectroscopy. J Am Chem Soc 114 3139-3141, 1992. 

Valiullin R, Kortunov P, Karger J, Timoshenko V (2004) Concentration-dependent self-diffusion of liquids in nanopores a nuclear magnetic resonance study. J Chem Phys 120(24) 11804-11814 Valiullin R, Khokhlov A (2006) Orientational ordering of linear n-alkanes in silicon nanotubes. Phys Rev E 73(5) 051604-051605... 

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