Novolin - Insulin

NPH Isophane Human Insulin Suspension. NPH isophane insulin, also called Humulin N, Insulatard NPH Human, or Novolin N is an intermediate-acting form of human insulin produced by recombinant DNA techniques. Mixtures Humulin 70/30 and Novolin 70/30 contain 70% NPH isophane and 30% regular, whereas Humulin 50/50 contains 50% NPH isophane and 50% regular. It is adrninistered subcutaneously and should not be given intravenously. Absorption is delayed because the insulin is conjugated with protamine in a complex of reduced isoelectric solubiUty. Therapeutically, this preparation is probably comparable to purified porcine NPH insulin. However, human NPH insulin may have a slightly shorter duration of action than comparable purified porcine products. 

Cartridges 100 units/mL (human insulin [rDNA]). For use with NovoPen and Novolin Pen otc) Novolin R PenPill (Novo Nordisk)... 

Commercially available insuhns differ in their onset of action, maximal activity, and duration of action (Table 67.3). They can be classified as rapid acting (0-5 hours), short acting (0-8 hours), intermediate acting (2 to 16 hours), and long acting (4 to 36 hours). Human insulin (e.g. Humulin, Novolin) produced by rDNA technology is now widely available and has largely supplanted in-... 

Brand Name(s) Intermediate- and short-acting mixtures Humulin 50/50, Humulin 70/30, Humalog Mix 75/25, Humalog Mix 50/50, Novolin 70/30, Novolog Mix 70/30 Cfiemical Class Exogenous insulin... 

Novolin is available in four formulations Regular (R), NPH (N), Lente (L), and Novolin 70/30. They correspond to the several formulations of Humulin. Novolin 70/30, Novolin N, and Novolin R are supplied in prefilled cartridges and in prefilled disposable syringes. Velosulin BR is a sterile solution of human insulin (rDNA origin) in a phosphate buffer. 

Hormones Insulin, human recombinant (yeast, S. cerevisiae) Novolin 5.8... 

Human Insulin (Recombinant) Humulin, Novolin, Velosulin BR 215... 

Novolin R Novo Nordisk human insulin too U/mL to mL vials... 

Regular insulin 0.5-1 2-4 5-7 Humulin R Novolin R Regular lletin II... 

Isophane insulin 3-4 6-12 18-28 Humulin N Novolin N NPH Insulin NPH Purified Insulin NPH lletin II... 

Insulin zinc 1-3 8-12 18-28 Humulin L Novolin L Lente Insulin Lente Insulin II... 

Novo Nordisk human insulins are termed Novolin R, L, and N. 

Human insulin from E coli is available for clinical use as Humulin (Lilly) and dispensed as either regular, NPH, lente, or ultralente Humulin. Human insulin prepared biosynthetically in yeast is marketed by Novo Nordisk as human insulin injection in regular, lente, and NPH forms Novolin R, Monotard Human Insulin (Novolin L), and Novolin N. The same company also produces a human insulin marketed as Velosulin (regular) that contains a phosphate buffer. This reduces aggregation of regular insulin molecules when used in infusion pumps. However, because of the tendency of phosphate to precipitate zinc ions, Velosulin should not be mixed with any of the lente insulins. 

Cerevisiae Rapid growth, low cost modification Novolin-B (insulin)... 

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