Novolin

NPH Isophane Human Insulin Suspension. NPH isophane insulin, also called Humulin N, Insulatard NPH Human, or Novolin N is an intermediate-acting form of human insulin produced by recombinant DNA techniques. Mixtures Humulin 70/30 and Novolin 70/30 contain 70% NPH isophane and 30% regular, whereas Humulin 50/50 contains 50% NPH isophane and 50% regular. It is adrninistered subcutaneously and should not be given intravenously. Absorption is delayed because the insulin is conjugated with protamine in a complex of reduced isoelectric solubiUty. Therapeutically, this preparation is probably comparable to purified porcine NPH insulin. However, human NPH insulin may have a slightly shorter duration of action than comparable purified porcine products. 

Novolin R Novo-Nordisk U-100 1 0 mL vial, 3 mL cartridge, 3 mL Innolet... 

Novolin 70/30 70% NPH 30% regular premix (Squibb-Novo) 100 Human, semisynthetic... 

Many drugs are administered as parenterals for speed of action because the patient is unable to take oral medication or because the drug is a macromolecule such as a protein that is unable to be orally absorbed intact due to stability and permeability issues. The U.S. Pharmacopoeia defines parenteral articles as preparations intended for injection through the skin or other external boundary tissue, rather than through the alimentary canal. They include intravenous, intramuscular, or subcutaneous injections. Intravenous injections are classified as small volume (<100 mL per container) or large volume (>100 mL per container) injections. The majority of parenteral dosage forms are supplied as ready-to-use solutions or reconstituted into solutions prior to administration. Suspension formulations may also be used,101 although their use is more limited to a subcutaneous (i.e., Novolin Penfill NOVO Nordisk) or intramuscular (i.e., Sandostatin LAR Depot Novartis) injection. Intravenous use of disperse systems is possible but limited (i.e., Doxil Injection Ortho Biotec). 

The market for biopharmaceuticals is over 90 bilhon. The most well-known products of the modem biotechnology industry are the mammahan polypeptides such as erythropoietin (EPO) with an 14 bilhon market human insuhn (Novolin and Humuhn), 5.6 bilhon interferon alpha (Intron... 

Cartridges 100 units/mL (human insulin [rDNA]). For use with NovoPen and Novolin Pen otc) Novolin R PenPill (Novo Nordisk)... 

Aspart protamine/aspart) Humulin 70/30, Novolin 0.5-1 Dual Up to 10-16... 

Novolin (rhinsulin) Novo Nordisk Diabetes mellitus 1991 (USA)... 

Commercially available insuhns differ in their onset of action, maximal activity, and duration of action (Table 67.3). They can be classified as rapid acting (0-5 hours), short acting (0-8 hours), intermediate acting (2 to 16 hours), and long acting (4 to 36 hours). Human insulin (e.g. Humulin, Novolin) produced by rDNA technology is now widely available and has largely supplanted in-... 

Brand Name(s) Intermediate- and short-acting mixtures Humulin 50/50, Humulin 70/30, Humalog Mix 75/25, Humalog Mix 50/50, Novolin 70/30, Novolog Mix 70/30 Cfiemical Class Exogenous insulin... 

Rapid Acting Humulin R, Novolin R, Novolog, Humalog, Regular Ilefin II. 

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