Novartis ritalin

Tablets 5, 10, and 20 mg (c-/7) Various, Ritalin (Novartis), Methylin (Mallinckrodt)...

Capsules, extended-release 10, 20, and 30 mg c-ii) Metadata CD (Celltech), Ritalin LA (Novartis)... 

Ritalin LA (package insert). East Hanover, NJ, Novartis Pharmaceutical Corp, 2004... 

Physician s Desk Reference. Ritalin Hydrochloride Tablets, Ritalin-SR Tablets (Novartis). Montvale, NJ Medical Economics, 2001. 

Ritalin has been hailed by many parents and teachers as a miracle pill once described by its makers (Novartis, formerly Ciba-Geigy Pharmaceuticals) as a mild central nervous system stimulant and by the New York Times as a mild stimulant that is roughly [equivalent to] a jolt of strong coffee. 24 These statements belie the fact that Ritalin has been known, since it was first marketed in the mid-1950s, to be a highly addictive drug subject to widespread abuse. 

As the DEA was taking the usual steps to prepare its preliminary response, in which it planned to deny CHADD s petition, the Merrow Report (a team of journalists) produced a television documentary on the ADHD-Ritalin epidemic. When it aired on PBS in October 1995, the documentary revealed a connection between Ritalin s manufacturer—then Ciba-Geigy, now Novartis—and CHADD. Ciba-Geigy had contributed nearly 900,000 to CHADD over five years, a fact... 

Ritalin (Novartis, 1955, racemate) Concerta (Johnson and Johnson, 2000) Focalin (Celgene/Novartis, 2001) Daytrana (Shire, 2006)... 

D Ritalin (Novartis Pharma) I Ritalin (Ciba) wfm USA Ritalin (Novartis)... 

The Web site sounds innocent enough ADHDinfo.com. But it is sponsored by Novartis, the manufacturer of Ritalin. It opens with the question, What causes attention-deficit/hyperactivity disorder (ADHD) in school-age children It answers, The exact cause of ADHD is not known. Scientists think that ADHD may be caused by an imbalance of chemicals in the brain that help to control behavior. So your hyperactive child does not need better discipline he needs a corrected biochemical imbalance. So your inattentive daughter does not need a more interesting classroom she, too, just needs to get those pesky chemicals corrected. 

CIBA-Geigy (now Novartis) manufactures Ritalin, the stimulant that, at the time, held the lion s share of the ADHD market. 

Trade names Centedrin Concerta Daytrana Metadate CD (Celltech) Methylin (Mallinckrodt) Rilatine Ritalin (Novartis) Rubifen... 

Methylphen idate Ritalin (Novartis), generics (various) 30-80... 

Ritalin (Methylphenidate hydrochloride). Novartis Pharmaceuticals UK Ltd UK Summary of product characteristics, June 2007. 

Product information Ritalin(R), methylphenidate. Gainesville, GA Novartis. 

A research group at Novartis also utilized Evans aldol reaction in a straightforward synthesis of (/ ,/ )-methylphenidate hydrochloride (ritalin hydrochloride), the drug well known for the treatment of attention deficit hyperactivity disorder (AD HD). In the key step, displayed in Scheme 4.58, N-acylated oxazolidinone 249, the standard boron enolate addition to 5-chloropentanal, yielded 250 as a single diastereomer that was transformed in several steps into Ritalin hydrochloride. In the aldol step, temperatures lower than -20 °C could be avoided, what makes the procedure applicable in a manufacturing scale [130]. 

Scheme 4.58 Evans aldol protocol as the key step in Novartis synthesis of ritalin.

Methylphenidate hydrochloride (Ritalin and Concerta [Novartis, Basel, Switzerland]) (11, Scheme 2.1) is a mild nervous system stimulant that is primarily prescribed for treatment of attention deficit hyperactivity disorder in children. Although it is marketed in its racemic form, it has been reported that the (+) enantiomer is 5 to 38 times more active than its racemate.Although previous syntheses of (+)-methylphenidate involved classic resolution, researchers at Novartis reported an enantioselective synthesis of (+)-methylphenidate in 1997. As depicted in Scheme 2.1, the synthesis began with a diastereoselective... 

---