Methylphenidate hydrochloride

Adverse reactions with other methylphenidate hydrochloride products -Nervousness and insomnia are the most common adverse reactions reported with other methylphenidate products. In children, loss of appetite, abdominal pain, weight loss during prolonged therapy, insomnia, and tachycardia may occur more frequently however, any of the other adverse reactions listed also may occur. 

Drugs that may affect methylphenidate include MAOIs. Drugs that may be affected by methylphenidate hydrochloride include guanethidine, anticonvulsants (eg, phenytoin, phenobarbital, primidone), selective serotonin reuptake inhibitors, coumarin anticoagulants, and tricyclic antidepressants. 

Amphetamines (excluding methylphenidate hydrochloride and anorexics) Stimulate adverse CNS effects. High... 

Chan, Y.P., Swanson, J.M., Soldin, S.S., Thiessen, JJ-, and Macleod, S.M. (1983) Methylphenidate hydrochloride given with or before breakfast II. Effects on plasma concentration of methylphenidate and ritalinic acid. Pediatrics 72 56-59. 

Dunnick, J., and Hailey, J. (1995) Experimental studies on the longterm effects of methylphenidate hydrochloride. Toxicology 103 77-84. 

Methylphenidate hydrochloride, a piperidine derivative structurally similar to amphetamine, is a commonly prescribed stimulant for the treatment of ADHD in children age 6 years and older. It is a racemic mixture of d,l methyl a-phenyl-2-piperidineacetate hydrochloride. The drug is available in immediate-release, extended-release, and controlled-release formulations. It is hepatically metabolized to an inactive metabolite and excreted by the kidneys. 

HA, mild pain Action Nonnarco tic analgesic w/ barbiturate Dose 1—2 tabs or caps PO q4-6h PRN i in renal/hepatic impair 4 g/24 h APAP max Caution [C, D, +] Alcoholic liver Dz Contra G6PD deficiency Disp Caps, Liq, tabs SE Drowsiness, dizziness, hangover effect Interactions T Effects OF benzodiazepines, opiate analgesics, sedatives/hypnotics, EtOH, methylphenidate hydrochloride i effects OF MAOIs, TCAs, corticosteroids, theophylline, OCPs, BBs, doxycycline EMS See Acetaminophen may impair coordination, monitor for depression concurrent EtOH use T CNS depression butalbital is habit forming... 

Methylphenidate hydrochloride. 2. Attention-deficit hyperactivity disorder. I. Title. II. Series. 

Infra-red Spectrum. Principal peaks at wavenumbers 1735,1175, 1210,1150,705,740 (methylphenidate hydrochloride, KCldisk). 

Fenfluramine Hydrochloride Clorprenaline Hydrochloride Lysergic Acid Stilboestrol Dichlorophen Bufylline Orphenadrine Meptazinol Hydrochloride Methylphenidate Hydrochloride Halazone Sulphamethizole Tolbutamide Doxylamine Hexoestrol Oestrone Mecloqualone Nordazepam Chloroprocaine Medazepam Carbutamide Normorphine Pilocarpine Nitrate Sulphapyridine Sodium Cyclazocine Dextromethorphan Methoprotryne Meprylcaine Hydrochloride Procainamide Hydrochloride Muzolimine Clorgyline... 

Dexmethylphenidate—Novartis/Celgene. Focalin, D-MPH, D-methylphenidate hydrochloride, D-methylphenidate, dexmethylphenidate, dexmethylphenidate hydrochloride. Drugs R D. 2002 3(4) 279-82. 

Central Nervous System Stimulants Central nervous system stimulants include agents such as the amphetamines (Dexedrine) and methylphenidate hydrochloride (Ritalin), used to elevate mood, suppress appetite, and control hyperkinetic disorders in children. Other examples include the illegal drugs methamphet-amine and cocaine. The mechanism of action of these drugs is to augment actions of the adrenergic nervous system. 

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