Novartis

Novartis uses the In Silico Profiling web tool. Available properties include the octanol water partition coefficient log P, molar refractivity, flexibility index, hydrogen bonding characteristics and molecular polar surface area. Various drug properties, such as intestinal absorption, BBB permeability or Plasma Protein Binding (PPB) are calculated based on in-house models. [Pg.242]

A high-throughput binding screen of the Novartis compound file identified a potent hit, 5, which the authors hypothesized had a dose structural similarity to the Schering CCR5 antagonist, SCH-C. Crossover compounds were prepared and [Pg.214]

8h in both species) with a similar pharmacologic profile to 6 (human binding IC50 5 nM, monkey IC50 8nM, calcium mobilization IC50 64nM). NIBR-1282 has demonstrated in vivo efficacy in a monkey model of kidnqr transplantation, but only in combination with cyclosporine A. No antiviral data is available for NIBR-1282. [Pg.215]

P. Ertl, O. Jacob, J. Mol. Struct. (THEOCHEM) 1997, 419, 113-120. http //jchempaint.sourceforge.net Representative sites which use the JME applet are listed at www.molinspira-tion.com/jme and the JME editor may be obtained from peter.ertl pharma. novartis.com... [Pg.168]

The development of a new drug is both a time-consuming and a cost-intensive process. It takes 12 to 15 years and costs up to 800 million to bring a new drug to the market. As measured by the market capitalization, the pharmaceutical companies play a pivotal role in the global economy. In February 2003 Pfizer was ranked at position five worldwide, with a market capitalization of 163 billion. Ranking third as far as the market capitalization in Europe is concerned was GlaxoSmithKline, with a current value of 101 billion. Novartis was number five in Europe with 82 billion. [Pg.598]

Robert T. Hammann, BP Amoco Corporation Russell Kahn, Novartis Crop Protection, Inc. [Pg.228]

Joseph M. Kulak, Novartis Consumer Health Division Edward J. Ryczek, Merck Company, Inc. [Pg.228]

Harcros Chemical Mil-Spec Industries Nippon Carbide Industries (Japan) Novartis (France)... [Pg.32]

Note Formed from the agro units of Novartis (formerly Ciba and Sandoz) and AstraZeneca (Zeneca Agio units). [Pg.205]

Novartis Crop Protection Unit, See Syngenta (Switzerland)... [Pg.240]

Novartis Crop Protection Unit, See Syngenta (Switzerland), 240 Novartis Phamta, 204 Noviant Oy, 155 Novotech Inc., 240... [Pg.342]

Klaus Seuwen, Marie-Gabrielle Ludwig Novartis Institutes for Biomedical Research, Switzerland... [Pg.1035]

Evelyn Back Novartis Pharma GmbH Nurnberg Germany... [Pg.1512]

Christine Huppertz Pharma Research Novartis Pharma AG Switzerland... [Pg.1518]

Psychiatry/Neuroscience Research Novartis Institutes for Biomedical Research Basel Basel... [Pg.1518]

Klaus. seuwen novartis. com Char-Chang Shieh... [Pg.1527]

Kilios (Carlo Erba) numerous combination preparations generic preparations Acuprin (Richwood) Ecotrin (SmithKline Beecham Consumer) Equagesic (Wyeth-Ayerst) Fiorinal (Novartis) Halfprin (Kramer) Norgeric (3M)... [Pg.29]

Moduretic (Du Pont 1970) Navispare (Novartis)-comb. Moduretic (Merck Sharp Dohme 1975)-comb. Midamor (Merck Sharp Dohme 1981)... [Pg.90]

Ophtalmin (Winzcr)-comb. I Antistin Privina (Novartis)- Patch) wfm... [Pg.129]

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