Novartis grants from

Another important acid derived from the corresponding unsamrated acid family is the a-alkyl substituted acid (C). This compound is used in the synthesis of Aliskiren (the active ingredient of Tektuma ) which Novartis has recently been granted FDA approval as the first-in-class renin inhibitor for control of blood pressure. It is estimated that large volumes of this intermediate will be required in the future but the best ee reported so far for production of this intermediate is 95 % as shown in Figure 1.8. ... 

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