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Notch signalling

Skeath JB, Doe CQ 1998 Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fate in the Drosophila CNS. Development 125 1857-1865 Spana E, Doe CQ 1995 The prospero transcription factor is asymmetrically localised to the cell cortex during neuroblast mitosis in Drosophila. Development 121 3187-3195 Spana E, Doe CQ 1996 Numb antagonises Notch signaling to specify sibling neuron cell fate. Neuron 17 21—26... [Pg.151]

Greenwaldl 1998 LIN-12/Notch signalling lessons from worms and flies. Genes Dev 12 1751-1762... [Pg.220]

Sestan, N., Artavanis-Tsakonas, S. and Rakic, P. (1999), Contact-dependent inhibition of cortical neurite growth mediated by Notch signaling , Science, 286, 741-746. [Pg.187]

Li, T., Ma, G., Cai, H. etal. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. /. Neurosci. 23 3272-3277, 2003. [Pg.789]

Goutte, C., Tsunozaki, M., Hale, V. A. and Priess, J. R. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl Acad. Sci. USA 99 775-779, 2002. [Pg.789]

Itoh, M., et al., Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell, 2003, 4(1), 67-82. [Pg.93]

There is thus a multiplicity of negative feedback processes that could, in principle, give rise to oscillations in Notch signaling, and on which the... [Pg.277]

The Notch signaling pathway is thus a further example of signal conduction in which the signal is directed by the shortest pathway from the cell membrane into the nucleus. [Pg.380]

Fig. 12.2. Model of Notch signalling. The Notch protein is a ligand activated transmembrane receptor which is subject to proteolysis of the intracellular domain upon ligand binding. The nature of the protease involved is still a matter of debate. The proteolytically released intranceUu-lar domain of Notch (NICD) translocates into the nucleus where it interacts with a family of transcription factors, the CSL proteins, resulting in a change in transcription of target genes. Fig. 12.2. Model of Notch signalling. The Notch protein is a ligand activated transmembrane receptor which is subject to proteolysis of the intracellular domain upon ligand binding. The nature of the protease involved is still a matter of debate. The proteolytically released intranceUu-lar domain of Notch (NICD) translocates into the nucleus where it interacts with a family of transcription factors, the CSL proteins, resulting in a change in transcription of target genes.
Artavanis-Tsakonas, S., Rand, M.D. and Lake, R.I Notch signaling cell fate control and signal... [Pg.384]

In general, Notch signaling is necessary for cell fate determination, cell proliferation and differentiation. Therefore, we focused on Notch signaling in the developing mouse mandibular condylar cartilage. The examination results are summarized as follows. At E14, in... [Pg.125]

Chiba S.(2006) Notch signaling in stem cell systems. Stem Cell 24 2437-2447. [Pg.137]

Shimizu T, Nakano K, Tsujigiwa H, Nagatsuka H, Watanabe T, Okafuji N, Kurihara S, Hasegawa H, Nagai N and Kawakami T (2007) Notch signaling in mandibular condylar cartilage development. Eur. J. Med. Res. 12 515-519. [Pg.139]

Zine A, Van De Water TR and de Ribaupierre F (2000) Notch signaling regulates the pattern of auditory hair cell differentiation in mammals. Development 127 3373-3383. [Pg.141]

Kawakami T and Shimizu T (2009) Role of Notch signaling in mouse mandibular condylat cartilage development. Acta. Anat. Nipponica 84(S) 69. [Pg.141]

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