Notch pathway

Oscillations of the segmentation clock with a period of 2 h have also been observed in fibroblast cell cultures following serum shock. There also, oscillations in the expression of the gene Hesl related to the Notch pathway have been attributed to negative feedback on transcription [171]. The periodic operation of the segmentation clock was recently demonstrated in cells of the PSM, where intercellular coupling is needed to prevent damping of the oscillations [172]. 

Francis, R., McGrath, G., Zhang, G., et al. (2002) Aph-1 and pen-2 are required for Notch pathway signalhng, gamma-secretase cleavage of beta-APP, and presenilin protein accumulation. Dev. Cell, 3, 85-97. 

Thurber AE, Douglas G, Sturm EC et al (2011) Inverse expression states of the BRN2 and MITE transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway. Oncogene 30 3036-3048... 

Jagged is developmentally regulated in neurons and activates the Notch pathway in OPCs, which inhibits their differentiation into oligodendrocytes (Givogri et al.,... 

NiranjanT, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K.The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med. 2008 14 (3) 290-298... 

Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation and function by the Notch pathway. An Rev Immunol 2005 23 945-74. 

Yoo AS, Bais C, Greenwald I. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science 2004 303 663-666. 

Fan X, Matsui W, Khaki L et al. (2006) Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 66 7445-7452... 

Hayward SD. Viral interactions with the Notch pathway. Semin Cancer Biol. 

A variety of ludferase-based reporters for monitoring diverse cell biological processes are commercially available. For example, ludferase-based reporters of other pathways such as the BMP and Notch pathways can be used for similar multiplexed lucifer-ase screening projects. 

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