Nostoc linckia

Other macrocyclic polyket naracvclophanes cylindrocyciophanes (Cylindrospermum licheniforme Kutzing, Nostocales, from American Type Culture Collection, and nostocyclophanes from Nostoc linckia (Roth) Bomet ex Bomet Flahault, from Univ. of Texas Culture Collection, freshwater Cyanobact. Hoye 2000). 

Nostocyclophane D (183) was obtained as the major toxin from the cyanophyte Nostoc linckia [144]. 

Hemscheidt, T., Puglisi, M. R, Larsen, L. K., Patterson, G. M. L., Moore, R. E., Rios, J. L., and Clardy, J., Structure and biosynthesis of borophycin, a new boeseken complex of boric acid from a marine strain of the blue green alga Nostoc linckia, J. Org. Chem., 59, 3467, 1994. 

Borophycin (15) was found to display appreciable c5dotoxicity against LoVo cells (MIC 0.066 pg/mL) and KB cells (MIC 3.3 pg/mL). It was isolated from the lipophilic extract of a marine strain of the blue-green alga Nostoc linckia [53]. Borophycin is made up of two identical halves with an overall structure reminiscent of other boron-containing antibiotics. The C3 starter unit for the biosynthesis of 15 is derived from acetate and methionine, but not propionate. 

Strains studied were as follows Anabaena sp. PCC7120, Anabaena cylindrica IAM M-l, Anabaena variabilis IAM M-58, Anabaenopsis circularis IAM M-4, Nostoc muscorum IAM M-14, Nostoc linckia IAM M-30, Nostoc commune IAM M-13, Nostoc carneum IAM M-35, Cylindrospermum muscicola IAM M-32, Anabaena cylindrica UTEX B 629, Anabaena flos-aquae UTEX 1444, and Anabaena flos-aquae UTEX LB 2558. Anabaena sp. PCC7120 was kindly donated by Dr. Ohmori of the University of Tokyo. UTEX and IAM strains were obtained from the Culture Collection of Algae at the University of Texas and the Institute of Applied Microbiology, University of Tokyo, respectively. 

Compounds isolated from the genus Nostoc (order Nostocales, 73 compounds) have predominantly been isolated from unknown species (91%). Nostoc commune accounts for only 6% of the isolated compounds with Nostoc linckia, Nostoc muscorum, and Nostoc spongiaeforme, each responsible for about 1 %. 

The boron-containing polyketide borophycin (21) has been isolated and characterized by Moore and Clardy [43] from the blue-green alga Nostoc linckia. The structure of this new polyketide is closely related to that of the ionophoric antibiotics boromycin (22) isolated from a terrestrial strain of Streptomyces antibioticus, and aplasmomycin (23) from a marine strain... 

N. are the first, naturally occurring paracyclophanes (see table). They are isolated from the cyanobacterium Nostoc linckia. Four [7.7]paracyclophanes have been identified. They all have cytotoxic activity (IC50 1 -2 pg/mL) and antitumor properties. For isolation, see Lit, for structure elucidation, see Lit., for biosynthesis, see... 

Comparison of Growth of Micro-Algae Nostoc Linckia Chlorella sp. in Dilute Culture 927 N. Sen... 

COMPARISON OP GROWTH OF MICRO-ALGAE NOSTOC LINCKIA CHLORELLA SP IN DILUTE CULTURE. 

Tentative stereochem. shown by analogy with Boromycin, B-00693. Prod, by the blue-green alga Nostoc linckia. Cytotoxic agent. Cryst. (CH2Cl2/MeOH) (as Na salt). Md —23.1 (c, 1.4 in CHCI3) (as Na salt). CAS number refers to Na salt. 

Borophycin was isolated from the cyanobacterium Nostoc linckia in 1994. This cyclic polyester is dosely related to aplasmomycin A, another derivative containing an atom of boron, which occurs in Plasmodium berghei (Apicomplexa). 

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