Nonhealing wounds

It is used for pellagra (avitaminosis PP), atherosclerosis, liver disease, stomach and duodenum ulcers, and prolonged, nonhealing wounds and ulcers. Synonyms of this drag are niconacid, pemivit, enzycol, niacin, and others. 

Turner, N.J., Badylak, S.F., 2015. The use of biologic scaffolds in the treatment of chronic nonhealing wounds. Adv. Wound Care 4, 490-500. 

Acute and chronic wounds are associated with high levels of MMP-2 and MMP-9. These observations have led to the suggestion that nonhealing ulcers develop an environment containing high levels of activated MMPs, which results in chronic tissue turnover and failure of wound closure (SI, V2). MMP-9 has been implicated in blistering skin diseases and contact... 

Greer, N., Foman, N.A., MacDonald, R., Dorrian, J., Fitzgerald, P., Rutks, I., Wilt, T.J., 2013. Advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers. Annals of Internal Medicine 159 (8), 532. 

In other clinical examinations, nonhealing lower-extremity ulcers were treated with the BNC-based wound dressing DERMAFILL (Portal et al., 2009). The time required for 75% reduction in wound size was compared without and with the... 

Portal, O., Clark, W.A., Levinson, D.J., 2009. Microbial cellulose wound dressing in the treatment of nonhealing lower extremity ulcers. Wounds 21 (1), 1—3. 

Mulder, G., Tallis, A. J., Marshall, V. T., Mozingo, D., Phillips, L., Pierce, G. F., Chandler, L. A., and Sosnowski, B. K. 2009. Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GamSOl) Results of a phase 1/2 trial. Wound Repair and Regeneration, 17, 772-779. 

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