Nocardiopsis

A.ctinomadura sp. ATCC 53708 A.ctinomadura a rea PERM BP-83 jActinomadura sp. MI215-NP3 Nocardiopsis sp. 6270 PERM BP-717, yActinomadura oligospora NRRL 15878... 

Microorganisms such as Nocardiopsis sp., an actinomycete, can metabolize cis- and trans-chlo-rdane to at least eight solvent-soluble substances, including dichlorochlordene, oxychlordane, hep-tachlor, heptachlor endo-epoxide, chlordene chlorohydrin, and 3-hydroxy-trans-chlordane (Beeman and Matsumura 1981). Based on studies of chlordane metabolism in animals, four metabolic pathways are proposed (Feroz and Khan 1979a WHO 1984 Nomeir and Hajjar 1987 USEPA 1988) ... 

Soil The actinomycete Nocardiopsis sp. isolated from soil extensively degraded pure cis- and /ra/3s-chlordane to dichlorochlordene, oxychlordane, heptachlor, heptachlor e/ c/o-epoxide, chlordene chlorohydrin, and 3-hydroxy-traas-chlordane. Oxychlordane slowly degraded to 1-hydroxy-2-chlorochlordene (Beeman and Matsumura, 1981). In Hudson River, NY sediments, the presence of adsorbed chlordane suggests it is very persistent in this environment (Bopp et al., 1982). The reported half-life in soil is approximately 1 yr (Hartley and Kidd, 1987). 

Malbrancheamide (60) represents a novel type of CaM inhibitors although other natural indole alkaloids such as the unusual indole-carbazole alkaloids from a culture broth of a Nocardiopsis sp, namely K-252a-K252d, the brominated P-carbolines eudistomidins A and C, obtained... 

S. staurosporeus Anaya Actinomadura madurae A. melliaura Arcyria denudata Aspergillus flavus A. tubingensis Nocardia aerocoligenes Nocardiopsis dassonvillei Nocardiopsis sp. 

In 1989, Tanida et al. reported the isolation of a 10-methoxy derivative of staurosporine, TAN-999 (296) from the culture broths of Nocardiopsis dassonvillei C-71425 in its optically active form [a]o +42.0 (c 0.50, DME). This isolate functions as a macrophage activator, useful for the treatment of mycosis, bacterial infection, and cancer (291,292). 

D-Oleandrose and L-olivomycose (3-C-methyl-L-olivose) together with 6-de-oxy-4- O-methyl-L-glucosc are constituents of the oligosaccharide in apoptolidin, isolated from Nocardiopsis sp., which was the subject of intense synthetic and biological investigation because of its potential for the treatment of cancer.151 155... 

Two new indole nucleosides kahakamides A 256 and B 257 were isolated from the actinomycete Nocardiopsis dassonvillei which is obtained from a shallow water sediment sample collected from the island of Kauai, Hawaii. Compound 256 exhibited anti-microbial activity toward the Gram positive bacterium Bacillus subtilis. 

TAN-999 (2) and TAN-1030a (10) are produced by Nocardiopsis dassomillei C-71425 and Streptomyces sp. C-71799, respectively. They exhibited macrophage-activating... 

Kim, J. W., Adachi, H., Shin-ya, K., Hayakawa, Y, andSeto, H. (1997). Apoptolidin, anew apoptosis inducer in transformed cells from Nocardiopsis sp. J. Antibiot. 50, 628-630. 

Figure 2 Representative structures for all the clans of glycoside hydrolases (GH). GH-A Family 1, /3-glucosidase B from Paenibacillus polymyxa(PDB-. 209P) GH-B Family 16, endo-/3-1,3-glucanase from alkaliphilic Nocardiopsis sp. F96(PDB 2HYK) GH-C Family 11, xylanase A (PDB XInA) from Bacillus circulans (PDB 1BCX) GH-D Family 31, a-xylosidase (YicI) from coll K12 (PDB 1XSI) GH-E Family 33, frans-sialidase from T. cmzi (PDB 1 MRS) GH-F Family 43, /3-1,4-xylosidase from...

Naumova, I.B., Shashkov, A.S., Tul skaya, E.M., Streshinskaya, G.M., Kozlova, Y.I., Potekhina, N.V., Evtushenko, L.l. and Stackebrandt, E. (2001) Cell wall teichoic acids structural diversity, species specificity in the genus Nocardiopsis, and chemotaxonomic perspective. FEMS Microbiology Reviews 25,2 69-283. 

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