Nitrogen-containing derivatives

Interest in the mechanism and product distribution of thermal and photochemical transformations of aryl azides led to the isolation of some nitrogen-containing derivatives of heptafulvalene. Based on elemental analysis and spectroscopic data it has been suggested tentatively that the compound isolated following vapor-phase pyrolysis of azidopentafluoro-... 

Phthalic anhydride derivatives are also not typical precursors in phthalocyanine formation. Their use is of interest in cases where the substituents prohibit conversion of the anhydride to nitrogen-containing derivatives like phthalimides or phthalonitriles. 

Compound 65 or nitrogen-containing derivatives of it have sometimes been isolated. 

A useful method for obtaining indazoles in high yields involves treatment of ortho-azido phenyl ketones or aldehydes with hydrazine hydrate. When this reaction was applied to 3-azido-2-formylselenophene, selenolo[3,2-c] pyrazole (111) was obtained in low yield. The yield could not be improved when the amino derivative was prepared as an intermediate142 (Scheme 13). 2-Dialkylamino-5-formylselenophenes react with diazonium salts under deformylation conditions to give azo dyes (Eq. 39).143 Another nitrogen-containing derivative of selenophene is compound U2.144 ... 

Transformation of carboxylic acids, esters, alcohols, or ethers into nitriles [28] or other nitrogen containing derivatives [29]... 

The halogenation of alkanes in the presence of sulphur dioxide yields alkanesulphonyl chlorides (5.79), and these are made in large quantities for conversion to metal alkanesulphonates (used as emulsifiers in polymerizations) or to nitrogen-containing derivatives. The sulphur dioxide acts by trapping the alkyl radical it does not terminate the chain mechanism, and so quantum yields can be very high (—2000). 

A mixture of 1 equiv. of the appropriate amine (10 mmol) with 2 equiv. (20 mmol) of compounds la-c is introduced into a Pyrex tube, which was then placed in a microwave reactor and irradiated by microwave (60 W) in the absence of solvent for 20 min. The nitrogen containing derivatives 2a-c, 3a and 4a were extracted with dichloromethane and washed with water to eliminate the residual amine. The solvent of the dried organic solution was eliminated under reduced pressure. The white solids 2a-c were washed with diethylether and dried. The yellow oils 3a-4a were analyzed as such. 

In comparison with the oxygen- or nitrogen-containing derivatives of similar structure, the most expressed tendency to the formation of cyclic tautomers by intramolecular SH group addition to the C=N bond is exhibited by aldehyde and ketone thioacylhydrazones [for a review, see (88KGS3)]. 

Reviews have appeared that in part cover recent advances in the ring-chain tautomerism of the nitrogen-containing derivatives of 1,3-dicarbonyl compounds (95ZOB705) of the reaction products of alkenals, alkenones, and alkane-1,3-diones with hydrazines and hydroxylamines (950PP519) and of other compounds [95H(41)1805 95H(41 )2057]. 

Nitrogen-containing derivatives of carbonyl compounds are prone to facile oxidation by DIB. Under the proper conditions a geat variety of substrates afforded different types of products, as illustrated in Table 3.4. 

Ring-chain tautomerism of nitrogen-containing derivatives of /3-dicarbonyl compounds 90MI8. 

The replacement reaetion by poly functional nitrogen-containing derivatives, in particular, makes it possible to introduce multiple RCH2 groups into the same molecule. Thus, the reaction of indole Mannich bases with ammonia y ields bis- and tris-(3-indolyl) amines. Likewise, primary amines, hydrazine, and hydroxylamine can be bis-alkylated by several Mannich bases. 

Non-isohypsic transformations are especially important in the syntheses of various nitrogen-containing derivatives. A common route for obtaining amines is the reduction of nitrogen-containing derivatives of carboxylic acids (nitriles or amides), aldehydes and ketones (imines) ... 

We should also mention that simple nitrogen-containing derivatives of keto groups, such as 3-azo (D-150), 3-azine (D-5), and 3-hydrazone (D-15) derivatives, may also sometimes favorably affect the activity or the dissociation of activities, while others work in the opposite direction, such as 3-dimethylhydrazone (S-115,S-116) or 17-N-pyrrolidinium salt derivatives (E-15). 

Other Nitrogen-containing Derivatives of Ketones.—The Schmidt reaction of 6- and 7-oxo-steroids (with NaNj-polyphosphoric acid) gave the same lactams as the Beckmann rearrangements of the corresponding oximes. 

Other Nitrogen-containing Derivatives of Ketones Sapogenins Reactions of the Spiro-acetal System Reactions of Aldehydes, Carboxylic Acids, and their Derivatives Miscellaneous... 

The decomposition of diphosgene is catalysed in the presence of various nitrogen-containing derivatives, such as pyridine, quinoline, or tertiary amines, to give complete... 

This Section is not only the most voluminous, but is also important because of the mechanisms of formation involved and the biochemical role of the compoimds in numerous biological processes. This Section describes at least four different kinds of nitrogen-containing derivatives of D-fructose. 

The situation is quite opposite in the nitrogen containing derivatives (i. e. alkaloids) of secologanin. Many of them have marked, in most cases strong biological activities, which could even be applied for therapeutical purposes. 

---