Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Substituents nitro

A solution of trifluoroacetic acid in toluene was found to be advantageous for cydization of pyruvate hydrazoncs having nitro substituents[4]. p-Toluene-sulfonic acid or Amberlyst-15 in toluene has also been found to give excellent results in preparation of indole-2-carboxylale esters from pyruvate hydra-zoiies[5,6J. Acidic zeolite catalysts have been used with xylene as a solvent to convert phenylhydraziiies and ketones to indoles both in one-flask procedures and in a flow-through reactor[7]. [Pg.59]

The 2-nitrothiazole can be reduced to the corresponding aminothiazole by catalytic or chemical reduction (82, 85, 89). The 5-nitrothiazole can also be reduced with low yield to impure 5-aminothiazole (1, 85). All electrophilic substitution reactions are largely inhibited by the presence of the nitro substituent. Nevertheless, the nitration of 2-nitrothiazoIe to 2,4-dinitrothiazole can be accomplished (see Section IV). [Pg.577]

Operating with sodium benzenethiolate the only reaction observed is the thiophenoxydehalogenation, which is strongly favored by the activation performed by 5-nitro substituent, as previously reported (Scheme 15) (9). [Pg.579]

Because it may be oxidized to a carboxyl group (Section 11 13) a methyl group can be used to introduce the nitro substituent m the proper position... [Pg.506]

Table 19 3 lists the ionization constants of some substituted benzoic acids The largest effects are observed when strongly electron withdrawing substituents are ortho to the carboxyl group An o nitro substituent for example increases the acidity of benzoic acid 100 fold Substituent effects are small at positions meta and para to the carboxyl group In those cases the values are clustered m the range 3 5-4 5... [Pg.803]

The effect of o and p nitro substituents is cumulative as the following rate data demonstrate... [Pg.976]

The most common types of aryl halides m nucleophilic aromatic substitutions are those that bear o ox p nitro substituents Among other classes of reactive aryl halides a few merit special consideration One class includes highly fluormated aromatic compounds such as hexafluorobenzene which undergoes substitution of one of its fluorines on reac tion with nucleophiles such as sodium methoxide... [Pg.980]

The reaction of /V-henzylideneaniline (19) with alkynes leads to quinolines substituted in the heterocychc ting (56). Except for benzyhdenes bearing nitro substituents, the reaction occurs in good yield and under mild conditions. The method appears capable of elaboration. [Pg.392]

Reduction of Nitro Substituents. These reactions are very common in anaerobic environments and result in amine-substituted pesticides anaerobic bacteria capable of reducing nitrate to ammonia appear to be primarily responsible. All nitro-substituted pesticides appear to be susceptible to this transformation, eg, methyl parathion (7) (eq. 9), triduralin, and pendimethalin. [Pg.216]

The corresponding diazo component with a 6-nitro substituent gives Eriochrome Black T /7787-61-7] (18b, R = NO2) (Cl Mordant Black 11 Cl 14645) which is supposed to consist almost exclusively of the ortho compound. [Pg.428]

A mechanism of this type permits substitution of certain aromatic and ahphatic nitro compounds by a variety of nucleophiles. These reactions were discovered as the result of efforts to explain the mechanistic basis for high-yield carbon alkylation of the 2-nitropropane anion by p-nitrobenzyl chloride. p-Nitrobenzyl bromide and iodide and benzyl halides that do not contain a nitro substituent give mainly the unstable oxygen alkylation product with this ambident anion ... [Pg.727]

Clearly, the tertiaiy nature of the chloride would make an Sn2 mechanism highly unlikely. Furthermore, the nitro substituent is essential to the success of these reactions. Cumyl chloride itself undergoes elimination of HCl on reaction with amines. [Pg.729]

The nitro substituent is also preserved dunng fluoroester reduction with sodium borohydride [S3] (equation 67) Use of diborane itself allows reduction of nitrodifluoroacetanihde to the amine, Al-nitrodifluoroethylaniline [84] (equation 68)... [Pg.313]

Halogenoly n i of the nitro substituent in fluoroarenes or fluoroalkylarenes provides a route to the corresponding chloro compounds [47, 48 (equations 30 and 31)... [Pg.375]

A Hammett plot of the pK values of p-substituted phenols against the Op values shows serious deviations for the members of the series at the extremes of the o scale, that is, for substituents that are strongly electron donating or electron withdrawing. It was recognized very early that such deviations could be rectified by choosing an appropriate o value for such substituents in effect, this means a different model reaction was adopted. The chemical basis of the procedure can be illustrated with the p-nitro substituent. The p-nitrophenolate ion is stabilized by through resonance as shown in 2. [Pg.320]

Compare energies for meta and para-dinitrobenzenium ions (intermediates in nitration of nitrobenzene). Is the ordering the same as those observed for intermediates in toluene and aniline nitration Examine electrostatic potential maps. What does your result suggest about the electron donor/aceptor properties of the nitro substituent ... [Pg.189]

RS /RO ratio on the degree and type of activation is further confirmed in the latter system where the presence of a 6-nitro substituent increases the ratio to 1.8 or higher. [Pg.314]

Nitration differs from halogenation since here the strongly electron-withdrawing effects of the nitro substituents first introduced influence the reactivity and the positions of further introduced substituents. Therefore, it is possible to prepare under carefully controlled reaction conditions different substitution products.100 103 The preparation of the tetrasubstituted product cannot be achieved since the deactivating effects of three nitro groups are too strong.104... [Pg.604]

Testing for excess of nitrous acid at the end of the reaction. For this purpose starch-potassium iodide papers are best used, and these indicate nitrite in acid solution by turning blue instantaneously. With some practice, the nitrite reaction can be clearly distinguished from the coloration caused by certain diazo compounds, such as those bearing nitro substituents. The latter react only after 0.5 to 2 seconds. Often the difference becomes more marked after dilution of the diazo solution with concentrated hydrochloric acid. A properly conducted diazotization should exhibit on completion a very weak nitrite reaction, corresponding to an excess of about 10 4 m. [Pg.13]

The log rate versus acid strength curve for the latter compound is of the exact form expected for reactions of the free base, whilst that of the former compound is intermediate between this form and that obtained for the nitration of aniline and phenyltrimethylammonium ion, i.e. compounds which react as positive species. That these compounds react mainly or entirely via the free base is also indicated by the comparison of the rate coefficients in Table 8 with those in Table 5, from which it can be seen that the nitro substituent here only deactivates weakly, whilst the chloro substitutent appears to activate. In addition, both compounds show a solvent isotope effect (Table 9), the rate coefficients being lower for the deuterium-containing media, as expected since the free base concentration will be lower in these. [Pg.27]

Nitromethane has been used as a solvent for molecular bromination297. The bromination of polymethylbenzenes in nitromethane, acetic acid, and 1 1 mixtures of these solvents at 30 °C, showed that rates were much faster (about 330-fold) in nitromethane than in acetic acid. With nitromethane, in the bromine concentration range 0.01-0.02 M, the reaction was third-order in bromine. The relative deactivating effects of m-halogen substituents were measured in terms of the time taken for 10 % reaction to occur, and these values are given in Table 71 from which the relative reactivities in the different solvents are apparent the deactivating effects of the m-nitro substituent were obtained by comparison with the reactivity of chloromesitylene at different concentrations (0.035, 0.055 M) of reactants. The results for the nitro compounds were interpreted in the same way... [Pg.122]

The yield of sulfone was found to be dependent on the nature of substituents in the benzene ring, being high 85%) in the case of methyl substituents but low (= 50%) in the case of nitro substituents. [Pg.1110]

The synthesis of a PPV derivative, 94, with donor (di-n-hexylamino) and acceptor (nitro) substituents attached regioselectively to the PPV backbone, was published by Yu et al. following the Heck-type cross coupling approach [118] starting from an AB-type monomer (95). The red-orange polymer (94), which is soluble in THE, chloroform and 1,2-dichloroethane, displays a number-average molecular weight M of about 12,000. [Pg.208]

PART 5 AROMATIC COMPOUNDS WITH NITRO SUBSTITUENTS... [Pg.508]

A wide range of mechanisms are involved in the degradation and transformation of aromatic compounds with nitro substituents. These include reduction of the nitro group, and dioxygenation, monooxygenation, and reduction of the aromatic ring. A review devoted to 2,4,6-trinitrotolune is available (Esteve-Nunez et al. 2001). [Pg.509]


See other pages where Substituents nitro is mentioned: [Pg.216]    [Pg.96]    [Pg.121]    [Pg.36]    [Pg.393]    [Pg.163]    [Pg.240]    [Pg.240]    [Pg.240]    [Pg.297]    [Pg.562]    [Pg.580]    [Pg.333]    [Pg.147]    [Pg.159]    [Pg.161]    [Pg.169]    [Pg.306]    [Pg.110]    [Pg.660]   
See also in sourсe #XX -- [ Pg.301 ]

See also in sourсe #XX -- [ Pg.432 ]




SEARCH



Aromatic Compounds with Nitro Substituents

By Replacement of Alkoxy, Cyano, Nitro, or Oxo Substituents

Electron-withdrawing substituents carbonyl and nitro compounds

Nitro group substituent constants

Nitro, terminal substituents

Nitro-aromatic compounds substituents

© 2024 chempedia.info