Nitric oxide, biosynthesis

Forte P, Kneale BJ, Milne E, Chowienczyk PJ, Johnston A, Benjamin N, Ritter JM. 1998. Evidence for a difference in nitric oxide biosynthesis between healthy women and men. Hypertension 32 730-734. 

Marietta, M. A. (1989). Nitric oxide Biosynthesis and biological significance. Trends Biochem. Sci. 14, 488-492. 

Marsche, G., R. Heller, G. Fauler, A. Kovacevic, A. Nuszkowski, W. Graier, W. Sattler, and E. Malle. 2004. 2-Chlorohexadecanal derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis. 24(12) 2302-6. 

Pergola C, Rossi A, Dugo P, Cuzzocrea S, Sautebin L (2006) Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. Nitric Oxide 15 30... 

Arginase plays a crucial role in the regulation of diverse metabolic pathways such as ureagenesis and nitric oxide biosynthesis. Recentiy, the synthesis and evaluation of nonreactive arginine analogues as possible enzyme inhibitors or receptor antago-... 

Stadler, J., Barton, D., Beil-Moeller, H., Diekmann, S., Hierholzer, C., Erhard, W., and Heidecke, C.D. (1995). Hepatocyte nitric oxide biosynthesis inhibits glucose output and competes with urea synthesis for 1-arginine. Am. J. Physiol. 268, G183-G188. 

Arginine serves as the formamidine donor for creatine biosynthesis, participates in polyamine biosynthesis, and provides the nitrogen of nitric oxide (NO). 

Mayer B, Hemmens B Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 1998 22 477. 

Moncada, S., Palmer, RM.J. and Hi, E.A. (1989). Biosynthesis of nitric oxide from L-aiginine is a pathway for the regulation of cell function and communication. Biochem. Pharmacol. 38, 1709-1715. 

Ignarro, L. J., Biosynthesis and metabolism of endothelium-derived nitric oxide, Annu. Rev. Pharmacol. Toxicol. 30 (1990), p. 535-560... 

P. L., Wiseman, J. N. omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine,J. Biol. Chem. 266 (1991), p. 6259-6263... 

A convenient approach to the synthesis of 2-aryl-4-alkyl-13 -triazino[l,2-ajbenzimidazoles 113 from 2-aminobenzimidazole has been reported <98IJC(B)1283>. New 8-cyanopyridothieno[l,23]triazines 114 as inhibitors of nitric oxide and eicosanoid biosynthesis have been described <99JMC4720>. Synthesis of pyridodithienotriazines 115, from dithienopyrimidine derivatives, and their antihistaminic and cytotoxic activities have been reported <98EJM887>. 

Hutchinson, P. J. A., Palmer, R. M. J., and Moncada, S. (1987). Comparative pharmacology of EDRF and nitric oxide on vascular strips. Eur. J. Pharmacol. 141, 445-451. Ignarro, L, J. (1990). Biosynthesis and metabolism of endothelium-derived nitric oxide, Annu. Rev. Pharmacol. Toxicol. 30, 535-560. 

Dtapier, J. C., Hirling, H., Wietzerbin, J., Kaldy, P., and Kuhn, L. C. (1993). Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO J. 12, 3643-3649. 

III. BIOSYNTHESIS AND METABOLISM OF ENDOTHELIUM-DERIVED NITRIC OXIDE... 

Forstermann, U., Gorsky, L. D., Pollock, J. S., Ishii, K., Schmidt, H. H. H. W., Heller, M., and Murad, F. (1990). Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in NlE-115 neuroblastoma cells requires calcium and calmodulin. Mol. Pharmacol. 38, 7-13. 

FIGURE 22-31 Biosynthesis of nitric oxide. Both steps are catalyzed by nitric oxide synthase. The nitrogen of the NO is derived from the guanidino group of arginine. 

C) The antioxidant actions of flavonoids appear to participate in their antithrombotic action. Flavonoids bind to platelet membranes and scavenge platelet-generated lipid peroxides and free radicals, restoring the biosynthesis and the action of endothelial prostacyclin and nitric oxide (NO), respectively [49,88]. 

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