Flavonoid binding

MUELLER, L., GOODMAN, C.D., SILADY, R.A., WALBOT, V., AN9, a petunia glutathione 5-transferase required for anthocyanin sequestration is a flavonoid-binding protein, Plant Physiol., 2000,123,1561-1570. 

Nissler, L., Gebhardt, R., and Berger, S., Flavonoid binding to a multi-drug-resistance transporter protein an STD-NMR study. Anal Bioanal Chem., 379, 1045, 2004. 

Perez-Victoria, J.M. et al.. Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin. Biochemistry, 38, 1736, 1999. 

Huang, X. et al., 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAa receptors, J. Med. Chem., 44, 1883, 2001. 

C) The antioxidant actions of flavonoids appear to participate in their antithrombotic action. Flavonoids bind to platelet membranes and scavenge platelet-generated lipid peroxides and free radicals, restoring the biosynthesis and the action of endothelial prostacyclin and nitric oxide (NO), respectively [49,88]. 

NPA and other synthetic auxin transport inhibitors can block PAT when they are incorporated into the receiver blocks in a classical donor-to-receiver polar transport assay. Figure 4 shows that quercetin in receiver blocks can inhibit lAA arrival, but only for the first 2 h of the transport test. Thereafter, the radioactivity delivered to the receiver blocks is increased compared to controls. In some experiments lAA (or NAA) arrival in quercetin-containing receiver blocks is increased at earlier times. A crossover is never observed when NPA is used. Quercetin and other flavonoids bind strongly to cellulose [31 ] and, unlike NPA, do not diffuse away... 

Leopoldini M, Malaj N, Toscano M, Sindona G, Russo N (2010) On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA Reductase (HMGR) Enzyme. J Agr Pood Chem 58(19) 10768-10773. doi 10.1021/jfl02576j... 

Dekermendjian K, Kahnherg P, Witt MR, Sterner O, Nielsen M, Liljefors T. Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex. J Med Chem 1999 42(21) 4343 350. 

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