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Nigrostriatal system, lesions

Kirik, D. et al. (2000). Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson s model Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J. Neurosci. 20(12), 4686-4700. [Pg.217]

Brecknell JE, Haque NS, Du JS, Muir EM, Fidler PS, Hlavin ML, Fawcett JW, Dunnett SB (1996) Functional and anatomical reconstruction of the 6-hydroxydopamine lesioned nigrostriatal system of the adult rat. [Pg.185]

Hefti F, Melamed E, Wurtman RJ (1980) Partial lesions of the dopaminergic nigrostriatal system in rat brain biochemical characterization. Brain Res 795 123-137. [Pg.189]

This proposition was tested using a well-studied animal model of Parkinson s disease in which partial lesions of the nigrostriatal system are created by unilateral microinjection of the catecholamin-ergic-specific neurotoxin 6-hydroxydopamine (6-... [Pg.259]

Schober A, Peterziel H, Von Bartheld CS et al (2007) GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action. Neurobiol Dis 25 378-391... [Pg.122]

While the nigrostriatal pathways are ipsilateral some crossing occurs in fibres from the ventral tegmental AlO nucleus. These pathways are shown diagramatically in Fig. 7.1. Further details can be obtained from Moore and Bloom (1978) and Lindvall and Bjorkland (1978). The nuclei provide distinct loci for activating the dopamine systems for electrophysiological, release and behavioural studies and for their destruction by electrolytic lesion or injection of the toxin 6-hydroxydopamine (6-OHDA). [Pg.138]

People with Parkinson s disease show a specific degeneration of the nigrostriatal tract so DA must be linked in some way to the control of motor function. It is also known that an imbalance of DA function on the two sides of the rat brain, either by stimulation or lesion of one SN, causes off-line or rotational movement (Ungerstadt and Arbuthnott 1970). This is best shown some days after 6-OHDA lesion of one substantia nigra and its nigrostriatal pathway when systemic apomorphine (DA agonist) causes animals to turn away from the lesioned side (contraversive), presumably... [Pg.155]

Ungerstadt, U and Arbuthnott, GW (1970) Quantitative recording of rotational behaviour in rats after 6-hydroxy dopamine lesions of the nigrostriatal dopamine system. Brain Res. 24 485-493. [Pg.162]

Motor function(s) of the nigrostriatal dopamine system studies of lesions and behavior... [Pg.237]

KEY WORDS Motor systems behaviour 6-hydroxydopamine nigrostriatal lesions rats monkeys transgenic mice. [Pg.237]

Apicella P, Trouche E, Nieoullon A, Legallet E, Dusticier N (1990) Motor impairments and neurochemical changes after unilateral 6-hydroxydopamine lesion of the nigrostriatal dopaminergic system in monkeys. 35 655-666. [Pg.280]

Kirik D, Rosenblad C, Bjorklund A (1998) Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp Neurol 752 259-277. [Pg.290]

Mansour A, Meador-Woodruff JH, Camp DM, Robinson TE, Bunzow J, et al. 1990b. The effects of nigrostriatal 6-hydro-xydopamine lesions on dopamine D2 receptor mRNA and opioid systems. Prog Clin Biol Res 328 227-230. [Pg.194]

Neoplasms or strokes in the regions of the nigrostriatal pathways Traumatic lesions interrupting substantia nigra projections Normal-pressure hydrocephalus Parkinsonism with other neuronal system degenerations Wilson s disease (copper deposition in the brain)... [Pg.1078]

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See also in sourсe #XX -- [ Pg.333 ]



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Nigrostriatal lesions

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