Nigella

The alkaloid Nigellicine proved to be the pyridazino[l,2-u]indazolium-l 1-carboxylate (234) and forms yellow crystals (Scheme 77). It was isolated from the widely distributed herbaceous plant Nigella saliva L., which is used as a spice and for the treatment of various diseases (85TL2759). The structure was determined by an X-ray crystal structure analysis. The carboxylate bond distances are essentially equal (123.3 and 125.6 pm). An intramolecular hydrogen bond was found between the carboxylate oxygen atom and the hydroxy group. In mass spectrometry, the molecular peak was found at mjz —246 (20) and the base peak at mjz —202 which corresponds... 

The indazole alkaloid Nigellidine (269) (Scheme 88) which was described as a zwitterion, was detected in the seeds of Nigella saliva L. (Ranunculaceae) (95TL1993), which is an erect annual plant found in South Asia and is widely cultivated. The seeds are commonly believed to have carminative, stimulatory and diaphoretic properties (75PHA2759). An X-ray single crystal analysis was performed on the methyl chloride. It is... 

Damascenine, CjqHj3N03, is a nitrogenous compound of an alkaloidal nature, which is present in the oil of Nigella damascena to the extent of about 9 per cent. It can be extracted from the oil by shaking it with dilute hydrochloric acid, rendering the aqueous liquid alkaline and extracting the alkaline liquid with petroleum ether. 

Regular removal of flowers as they die will strengthen bulbs, and helps keep annuals and biennials looking good it may extend the flowering period. Do not deadhead plants such as honesty and nigella if you want to retain the attractive seedheads. 

Flepatic mixed function oxidase inhibition. Oleoresin, administered to rats at a dose of 250 mg%, was active " " ". Hypocholesterolemic activity. A hot mixture of Nigella sativa, Commiphora myrrha, Ferula assafoetida, Aloe vera, and Boswellia serrata, administered by gastric intubation to rats at a dose of 0.5 g/kg for 7 days, was active vs streptozotocin-induced hyperglycemia " " ". 

Glucosyl(l —> 2)galactosyl(l —> 2)glucoside Nigella saliva seeds Ranunculaceae 192... 

Merfort, I. et al., Flavonol triglycosides from seeds of Nigella sativa, Phytochemistry, 46, 359,1997. 

Haq A, Lobo PI, Al-Tufail M, Rama NR, Al-Sedairy ST. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. International Journal of Immunopharmacology 1999 21 283-295. 

Nigella sativa grains known in the Middle and Far East as black grain or black cumin has an inhibitory effect on clinical carcinogenesis, and the said effects are mediated via inhibition of... 

Damascenine (= Methyl Mgella damascena, M arvensis (Nigella seed) OD-R (nigella seed)... 

Menounos P., Staphylakis K., and Gegiou D. (1986) The sterols of Nigella sativa seed oil. Phytochemistry 25, 761-763. 

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