Solid dispersions nifedipine

Suzuki H, Sunada H. Comparision of nicotinamide, ethylurea and polyethylene glycol as carriers for nifedipine solid dispersion systems. Chem Pharm Bull 1997 45 1688-1693. 

Suzuki H, Sunada H. Influence of water-soluble polymers on the dissolution of nifedipine solid dispersions with combined carriers. Chem Pharm Bull 1998 46 482 -87. 

Vippagunta, S. R., K. A. Maul, S. Tallavajhala, and D. J. W. Grant. 2002. Solid-state characterization of nifedipine solid dispersion nt J Pharm236 111-123. 

Figure 5.11 Plot of the dissolved fraction >pt as a function of generations i (time step 5 min) using (5.24) for the dissolution of nifedipine solid dispersion with nicotinamide and polyvinylpyrolidone (1 3 1), in 900ml of distilled water. Fitted line of (5.24) is drawn over the experimental data.

Nifedipine. Solid dispersions of nifedipine with pyp[37] enteric polymers were evaluated in dogs and humans. PVP dispersions showed rapid absorption with a threefold increase in bioavailability when compared to physical mixtures. Sustained blood levels were obtained from solid dispersions with enteric polymers. 

Emara, L. H., Badr, R. M., and Elbary, A. A. 2002. Improving the dissolution and bioavailability of nifedipine using solid dispersions and solubilizeESug Develop. Ind. Pharm. 28 795-807. 

Hydroxypropyl Methylcellulose (HPMC) Suzuki and Sunada. report the production of solid dispersions prepared with nicotinamide and HPMC as combined carriers using nifedipine and nitrendipine as model drugs. Their solid dispersions were obtained using the fusion method. After both the drug and HPMC were dissolved in the liquid melt of nicotinamide at 140°C, the fused mixture was cooled to solidify it. 

Suzuki and Sunada " also prepared solid dispersions of nifedipine with other combined carriers using a fusion (melt) method. The combined carriers were nicotinamide and four different water-soluble polymers hydroypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP), partially hydrolyzed polyvinyl alcohol (PVA), and pullulan. HPMC, PVP, and PVA dissolved in the melt of nicotinamide and were effective in the amorphous formation of nifedipine in solid dispersions. In dissolution studies, the drug concentration... 

Chowdary KP, Ramesh KV. Microencapsulation of solid dispersions of nifedipine-novel approach for controlling drug release. Indian Drugs 1995 32(Oct) 477-483. 

Zajc, N., Obreza, A., Bele, M., and S. Srcic. Physical properties and dissolution behaviour of nifedipine/ mannitol solid dispersions prepared by hot melt method. Int J Pharm, 291 (2005) 51-58. 

Marsac PJ, Konno H, Taylor LS (2006a) A comparison of the physical stability of amorphous felodipine and nifedipine systems. Pharm Res 23(10) 2306-2316 Marsac PJ, ShambRn SL, Taylor LS (2006b) Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility. Pharm Res 23(10) 2417-2426 Marsac PJ, Li T, Taylor LS (2009) Estimation of drug-polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters. Pharm Res 26(1) 139-151... 

Aso Y, Yoshioka S (2006) Molecular mobility of nifedipine-PVP and phenobarbital-PVP solid dispersions as measured by C-NMR spin-lattice relaxation time. J Pharm Sci 95 318-325 Aso Y, Yoshioka S, Kojima S (2000) Relationship between the crystallization rates of amorphous nifedipine, phenobaibital, and flopropione, and their molecular mobility as measured by their enthalpy relaxation and H NMR relaxation times. J Pharm Sci 89 408-416 Aso Y, Yoshioka S, Zhang J, Zografi G (2002) Effect of water on the molecular mobility of sucrose and poly(vinylpyrrolidone) in a colyophUized formulation as measured by C-NMR relaxation time. Chem Pharm Bull 50 822-826... 

Aso Y, Yoshioka S, Miyazaki T, Kawanishi T, Tantika K, Kitamura S, Taktikura A, Hayashi T, Muranushi N. (2007) Miscibility of nifedipine and hydioplrilic polymers as measured by H-NMR spin-lattice relaxation. Chem Pharm Bull 55 1227-1231 Aso Y, Yoshioka S, Miyazaki T, Kawanishi T (2009) Feasibility of F-NMR for assessing the molecular mobility of flufenamic acid in solid dispersions. Chem Phtirm Bull 57 61-64... 

Cai T, Zhu L, Yu L (2011) Crystallization of oiganic glasses effects of polymer additives on bulk and surface crystal growth in amorphous nifedipine. Pharm Res 28 2458-2466 Calahan JL, Zanon RL, Alvarez-Nunez F, Munson EJ (2013) Isothermal microcalorimetry to investigate the phase separation for amorphous solid dispersions of AMG 517 with HPMC-AS. Mol... 

Yuan X, Sperger D, Munson EJ (2013) Investigating miscibility and molecular mobility of nifedipine-pvp amorphous solid dispersions using solid-state NMR spectroscopy. Mol Pharm ll(l) 329-337... 

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