Nidogen

Nicotinic acid adenine dinucleotide phosphate (NAA 315 Nicotinic acid hydroxylase 825 Nidogen 437 Ninhydrin 120,121s Nitrate reductase(s)... 

Glycoproteins Fibronectin, laminin, merosin, tenascin, nidogen, undulin, hyaluronic acid... 

The glomerular basement membrane (GBM) forms the backbone of the glomerular tuft. It is composed of three layers lamina rara interna, lamina densa, and lamina rara externa. The glomerular basement membrane is composed of a network of collagen type IV molecules (H5) intertwined with nidogen to another network composed of molecules of laminin. Type IV collagen and laminin are responsible for the firmness of the glomerular basement membrane and enable adhesion of endothelial cells and podocytes as well. 

Laminin [consisting of three polypeptide chains, A, Bl (possibly replaced in GBM by S) and B2] is the most important noncollagenous protein of the glomerular basement membrane. Laminin forms a second network, which is connected to the collagen IV network probably via another protein called entactin or nidogen. Laminin is probably very important for cellular differentiation and adhesion, but its mesh clearly also contributes to the structure of the glomerular basement membrane. The postnatally common embryonic laminin-10 isoform is... 

Nidogen/entactin Single chain (A/, 150K) Laminin binding... 

Fig. 3. Electron micrographs of type IV collagen (a), laminin (b), and nidogen (c) molecules after rotary shadowing. Bar in a-c, 50 nm.

Collagen IV has been found to bind to both laminin and heparan sulfate proteoglycan, whereas laminin binds both the nidogen and heparan sulfate proteoglycan. These observations suggest that multiple interactions of a specific nature could be important in determining both the composition and the deposition of basement membranes. 

Gerl, M., Mann, K., Aumailley, M., and Timpl, R. (1991). Localization of a major nidogen-binding site to domain III of laminin B2 chain. Eur. J. Biochem. 202, 167-174. 

Stetefeld, J., Mayer, U., Timpl, R., and Huber, R. (1996). Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin 7I chain harboring the nidogen binding site. J. Mol. Biol. 257, 644-657. 

Free Radicals Oxidative sdess appears to play a role in ALS pathogenesis, and studies of genes in the reactive oxidative pathways and reactive nidogen pathways are ongoing. 

Fibulin-1 is a glycoprotein that has been shown to be a component of the extracellular matrix that surrounds vascular smooth muscle. Fibulin-1 can bind to a number of matrix constituents including fibronectin, laminin, nidogen and fibrinogen. In fact, studies performed under flow conditions on fibulin-1 coated surfaces showed that this protein... 

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