Neuronal vulnerability

Anderson, K. and Talbot, K. Spinal muscular atrophies reveal motor neuron vulnerability to defects in ribonucleo-protein handling. Curr. Opin. Neurol. 16 595-599,2003. 

Mathur C, Prasad WK, Raju VS, et al Steroids and their conjugates in the mammalian brain. Proc Natl Acad Sci USA 90 85-88, 1993 Mattes JA A pilot study of combined trazodone and tryptophan in obsessive-compulsive disorder. Int Clin Psychopharmacol 1 170-173, 1986 Mattson MP, Cheng B, Davis D, et al Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12 376-389, 1992... 

Hirsch EC, Faucheux B, Damier P, Mouatt-Prigent A, Agid Y. 1997. Neuronal vulnerability in Parkinson s disease. J Neural Transm Suppl 50 79-88. 

Uz T., Pesold C., Longone P., and Manev H. (1998). Aging-associated up-regulation of neuronal 5-lipoxygenase expression putative role in neuronal vulnerability. FASEB J. 12 439 449. 

Bemaudin M., Nouvelot A., MacKenzie E. T., and Petit E. (1998). Selective neuronal vulnerability and specific glial reactions in hippocampal and neocortical organotypic cultures submitted to ischemia. Exp. Neurol. 150 30-39. 

II. p50/RelA and c-Rel-Containing Dimers Elicit Opposite Regulation of Neuron Vulnerability... 

Quantitative strategies to evaluate the effects of posttraumatic temperature patterns of neuronal vulnerability in models of TBI have been conducted in several laboratories. The effect of posttraumatic hypothermia on histopathological outcome was first evaluated in a model of moderate parasagittal fluid percussion (F-P) brain injury (3). In that... 

Mattson, M.P., Zhu, H., Yu, J., and Kindy, M.S., 2000b, Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture Involvement of perturbed calcium homeostasis. J. Neurosci. 20 1358-1364. 

Bergeron C, Petrunka C, Weyer L (1996) Copper/zinc superoxide dismutase expression in the human central nervous system. Correlation with selective neuronal vulnerability. Am J Pathol... 

Sattler, R., Charlton, M.P., Hafner, M., Tymianski, M. (1998). Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity. J. Neurochem. 71 2349-64. 

Masliah E, Ge N, Achim CL, Hansen LA, Wiley CA (1992) Selective neuronal vulnerability in HIV encephalitis. J Neuropathol Exp Neurol 51 585-593. 

Hunot S, Boissiere F, Faucheux B, Brugg B, Mouatt-Prigent A, Agjd Y, Hirsch EC (1996) Nitric oxide syiidiase and neuronal vulnerability in Parkinson s disease. Neuroscience 72 355—363. 

Sapolsky RM (1985) A mechanism for glucocordcoid toxicity in die hippocampus hicreased neuronal vulnerability to metabolic insults. J Neurosci 5 1228—1232. 

Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. 1992. /3-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12 379-89... 

Multiple polymorphic risk variants can increase neuronal vulnerability to premature death (see Table 1). 

RosenbergPA, AizenmanE (1989) Hundredfold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neurosci Lett 103(2) 162-168... 

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