Adhesion molecule on glia

Neuron-glial adhesion in nerve cell cultures is mediated by the pi subunit AMOG (adhesion molecule on glia) in the aipi isozyme of Na,K-ATPase [51]. Antibodies to the pi subunit dissociate cell-cell associations and also increase the rate of active... 

AMOG adhesion molecule on glia CBP CREB-binding protein... 

Other molecules involved in glia-neuron interactions belong to none of the above-mentioned protein families, e.g. adhesion molecule on glia (AMOG) and Astrotactin. The calcium-... 

The adhesion molecule on glia (AMOG/beta 2) and alpha 1 subunits assemble to functional sodium pumps in Xenopus oocytes. J. Biol. Chem. 267 20212-20216. 

TGF l and TGF/32 enhance the glia-mediated stimulation of neurite outgrowth of dorsal root ganglion cells due to expression of the neural adhesion molecule LI (Saad et al., 1991), an effect that is mediated via stimulated NGF production in immature astrocytes. On the other hand, Flanders et al. (1991) reported a decrease in survival of embryonic chick ciliary ganglion cells, when TGF/32 and 3 were added to the cultured... 

Well-studied CAMs of the Ig-family in the nervous system are the neural cell adhesion molecule (N-CAM) and the neuron-glia cell adhesion molecule (LI or NILE). Both molecules are found on neurons and have been suggested to mediate neuron-glia interactions by heterophilic binding mechanisms. Currently, it is unknown whether astroglia express N-CAM and/or LI in vivo (Persohn and Schachner, 1987 Bartsch et al.,... 

Other putative laminin-binding proteins have been described from a number of sources (for example, Smalheiser and Schwartz, 1987). Kleinman et al. (1991) used a synthetic peptide derived from the a chain of laminin to elute a 110 kDa protein from brain tissue however, the resulting molecule had sequence similarity to nucleolin. This putative receptor appears to be expressed in postnatal brain, particularly the hippocampus (Luckinbilledds et al., 1995). Albini et al. (1992) have described the isolation of a similar 100 kDa molecule from Y-79 retinoblastoma cells that is eluted from laminin affinity columns by 20 mM EDTA this binding protein has only intermediate affinity for laminin, however, but may act to influence gene expression independent of attachment. Laminin has been reported to bind to Ng-CAM on the basis of antibody inhibition studies, an interaction important for the formation of neuron-glia adhesion (Grumet etal., 1993). 

---